无溶剂芳香族克拉森重排法合成工业原料的连续流工艺开发

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Flow Chemistry Pub Date : 2023-07-14 DOI:10.1007/s41981-023-00275-z

Nikola Petrovic, Sándor B. Ötvös, C. Oliver Kappe

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引用次数: 0

摘要

报告采用高温连续流方案，通过相应二烯丙基醚前体的芳香族克莱森重排，强化合成一种重要的工业原料。该工艺利用了无溶剂条件的优势，从而最大限度地提高了生产率，同时降低了成本和对环境的影响。通过精确控制反应温度和停留时间，实现了高产和高选择性合成，与早期的批量方法相比，确保了放热转化的安全性和可扩展性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Continuous flow process development for the synthesis of an industrial raw material via solvent-free aromatic Claisen rearrangement

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Continuous flow process development for the synthesis of an industrial raw material via solvent-free aromatic Claisen rearrangement

A high-temperature continuous flow protocol is reported for the intensified synthesis of an important industrial raw material via aromatic Claisen rearrangement of the corresponding diallyl ether precursor. The process takes advantage of solvent-free conditions, thereby maximizing productivity whilst reducing cost and environmental impact. By precise control over reaction temperature and residence times, a high-yielding and selective synthesis is achieved that ensures improved safety and scalability of the exothermic transformation compared with earlier batch methodologies.

Graphical Abstract

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来源期刊

Journal of Flow Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

6.40

自引率

3.70%

发文量

审稿时长

>12 weeks

期刊介绍： The main focus of the journal is flow chemistry in inorganic, organic, analytical and process chemistry in the academic research as well as in applied research and development in the pharmaceutical, agrochemical, fine-chemical, petro- chemical, fragrance industry.