高分子生物医学植入物抗菌性能的表面设计策略

IF 4.7 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL
Elizabeth L. Meier, Yeongseon Jang
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引用次数: 2

摘要

医疗植入物在个人健康和生活质量方面发挥着至关重要的作用,可以替代、支持或增强身体中的生物结构。材料的选择,考虑到它们的性质,是至关重要的植入物取决于其应用领域。生物医学植入物中使用的聚合物种类繁多,需要材料的灵活性和运输能力。由于细菌在聚合物表面的粘附会导致严重的传染病和植入物的恶化,因此制定合理的表面设计策略非常重要。在此,我们重点介绍了合成的、不可生物降解的聚合物生物医学植入物和最近创造抗菌表面的策略。总结了不同类型的聚合物基植入物及其用途,以及它们固有的抗菌性能和附加的表面改性策略。最后,我们讨论了当前方法的挑战和未来的前景,以提高抗菌性能和获得聚合物基医疗植入物的多模态功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Surface design strategies of polymeric biomedical implants for antibacterial properties

Surface design strategies of polymeric biomedical implants for antibacterial properties

Medical implants play an essential role in individuals' health and quality of life to replace, support, or enhance a biological structure in bodies. The selection of materials, considering their properties, is critical for implants depending on their application areas. There is a wide range of polymers used in biomedical implants, where the materials' flexibility and transport capability are needed. Since bacterial adhesion on polymeric surfaces leads to serious infectious diseases and deterioration of the implants, the development of rational surface design strategies is of great importance. Herein, we highlight synthetic, non-biodegradable polymer-based biomedical implants and the recent strategies to create antibacterial surfaces. Different types of polymer-based implants with their uses are summarized, along with their inherent antibacterial properties and additional surface modification strategies. Finally, we discuss the challenges of the current approaches and future perspectives to enhance antibacterial performance and obtain multimodal functionality of polymer-based medical implants.

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来源期刊
Current Opinion in Biomedical Engineering
Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
2.60%
发文量
59
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