耳部瘢痕瘤手术刮除和病灶内注射的联合治疗:一项回顾性队列研究的早期结果

J. Tran, S. Lultschik, J. Ho, S. Sapra, Kevin Dong, Klaudija Gusic
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引用次数: 0

摘要

瘢痕疙瘩是一种肥厚性疤痕,通常出现在耳朵区域。作者的目的是(1)评估手术切除后局部注射曲安奈德和肉毒杆菌毒素a的有效性;(2)评价安全性和患者满意度。方法和材料本研究是对在单个皮肤科门诊接受外伤性手术剃须切除,然后局部注射曲安奈德和肉毒杆菌毒素治疗耳部瘢痕疙瘩的患者进行回顾性分析。对同一患者群体进行前瞻性患者问卷调查,以收集复发率和患者满意度。结果共纳入45例患者,女性占84.4% (n = 38),男性占15.6% (n = 7),平均年龄25.5岁。通过回顾性图表回顾,6.7%的患者(n = 3)出现早期复发,通过前瞻性患者问卷调查,11.1%的患者出现早期瘢痕疙瘩复发(n = 5)。在表达临床满意度的患者中,96.0% (n = 24)表示满意或非常满意,4.0% (n = 1)表示不满意。满意度也通过前瞻性患者问卷进行评估;在同意问卷调查的人中,100.0% (n = 24)表示满意或非常满意。只有20.0% (n = 9)的患者报告出现了副作用,包括瘙痒(11.1%;N = 5),压痛(4.4%;N = 2),疼痛(2.2%;N = 1),轻度萎缩(2.2%;n = 1)。结论外耳瘢痕切除后外耳内注射曲安奈德和肉毒杆菌毒素是治疗耳部瘢痕瘤的理想方法。证据水平:3项回顾性队列研究。瘢痕疙瘩是一种凸起的疤痕,患者会感到疼痛和瘙痒。瘢痕疙瘩可以出现在身体的各个部位,包括耳朵。它们很难治疗,而且容易复发。有许多治疗选择,然而,没有一个通用的最好的治疗耳朵上的瘢痕疙瘩。我们希望发现剃须切除后局部注射曲安奈德和肉毒杆菌毒素对治疗耳上的瘢痕疙瘩是否有效。为了回答这个问题,我们完成了一份临床患者的图表回顾,他们已经完成了以下耳上瘢痕疙瘩的联合治疗。瘢痕疙瘩的治疗首先是用手术刀物理去除大部分瘢痕疙瘩,这被称为剃须切除。取出后,将曲安奈德和肉毒杆菌毒素a直接注射到瘢痕疙瘩中。患者满意度和瘢痕疙瘩返回率收集在门诊访问和可选的门诊后患者问卷。在门诊访问期间报告了治疗效果和副作用。这表明,由于副作用率低,患者满意度高,瘢痕疙瘩复发率低,应考虑将该治疗组合作为耳部瘢痕疙瘩的一种选择。然而,由于这项综述是在一个诊所完成的,患者人数很少,因此尚不完全清楚这种治疗组合是否对所有患者都有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Concomitant therapy of surgical shave excision and intralesional injections for ear keloids: Early results from a retrospective cohort study
Introduction Keloids are hypertrophic scars that commonly arise in the ear region. The authors’ objectives were to (1) evaluate effectiveness of surgical shave excision followed by intralesional triamcinolone acetonide and onabotulinumtoxinA injections; and (2) evaluate safety and patient satisfaction. Methods and Materials This study was a retrospective chart review of patients who received treatment of extralesional surgical shave excision followed by intralesional triamcinolone acetonide and onabotulinumtoxinA injections to treat ear keloids at a single outpatient dermatology clinic. A prospective patient questionnaire was administered to the same patient population to collect recurrence and patient satisfaction. Results A total of 45 patients were included, consisting of 84.4% females (n = 38) and 15.6% males (n = 7) with a mean age of 25.5 years. Through retrospective chart review, early recurrence was seen in 6.7% of patients (n = 3), and via the prospective patient questionnaire, 11.1% of patients noted early keloid recurrence (n = 5). Of the patients who expressed their level of satisfaction in-clinic, 96.0% (n = 24) reported being satisfied or very satisfied and 4.0% (n = 1) were dissatisfied. Satisfaction was also assessed through the prospective patient questionnaire; of those who consented to the questionnaire, 100.0% (n = 24) were satisfied or very satisfied. Only 20.0% (n = 9) of all patients reported experiencing side effects, consisting of pruritus (11.1%; n = 5), tenderness (4.4%; n = 2), pain (2.2%; n = 1), and mild atrophy (2.2%; n = 1). Conclusion Extralesional surgical shave excision followed by intralesional triamcinolone acetonide and onabotulinumtoxinA injections may represent a promising treatment option for ear keloids. Evidence Level: 3 retrospective cohort study. Lay Summary Keloids are a type of raised scar, which can be painful and itchy for patients. Keloids can occur on various part of the body, including on the ear. They are challenging to treat and tend to come back. There are many treatment options, however, there is not one universal best treatment for keloids on the ear. We hoped to discover if shave excision followed by intralesional triamcinolone acetonide and onabotulinumtoxinA injections is effective at treating keloids on the ear. In order to answer this we completed a chart review of clinic patients, who have already completed the following combination treatment for keloids on the ear. The keloids were treated first by physically removing the bulk of the keloid with a scalpel, which is called shave excision. After the removal, triamcinolone acetonide and onabotulinumtoxinA were injected directly into the keloid. The rate of patient satisfaction and the rate of the keloid returning were collected during in-clinic visits and an optional post-clinic patient questionnaire. The treatment effectiveness and side effects experienced were reported during in-clinic visits. This indicated that with the low rate of side effects, high patient satisfaction, and low rate of keloid return, this treatment combination should be considered as an option for keloids on the ear. However, since this review was completed at one clinic with a small population of patients, it is not fully known if this treatment combination will work for all patients.
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