Vortioxetine-induced periorbital edema: An unusual case report

Drug-induced periorbital edema can be defined as extravasation of fluid to the extracellular space in periorbital tissues as a consequence of a pharmacologic agent. It is often a diagnosis of exclusion, arrived at after eliminating infection, nutritional, inflammation, and oncologic etiologies. In this case report, we wish to highlight a case of periorbital edema induced by vortioxetine. The authors describe a case of a 25-year-old male with a diagnosis of major depressive disorder, who developed periorbital edema after 5 days of taking vortioxetine. The authors observed a temporal relationship between periorbital edema and a new multimodal antidepressant-vortioxetine. This is the first reported case of periorbital edema due to vortioxetine in the literature. This can be of substantial importance as it is a relatively newer drug and will help psychiatrists to be more vigilant of this rare but serious side effect while prescribing the drug in their daily practice.