卡塔尔癌症中HPV、EBV和MMTV-样病毒的发病率

IF 3.2 4区医学 Q3 VIROLOGY

Intervirology Pub Date : 2022-05-31 DOI:10.1159/000525277

I. Gupta, Reem Al-Sarraf, H. Farghaly, S. Vranić, A. Sultan, Hamda A. Al-Thawadi, A. Al Moustafa, Halema F Al-Farsi

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引用次数: 3

摘要

简介:人乳头瘤病毒(hpv)、eb病毒(EBV)和小鼠乳腺肿瘤病毒样病毒(mmtv样病毒)可以存在并促进乳腺癌的发生和进展。然而，这些癌病毒及其串扰在乳腺癌中的作用尚不清楚。方法:采用PCR方法对卡塔尔74例乳腺癌标本中高危hpv、EBV和mmtv样病毒的共同存在情况进行了研究。结果:我们发现65%和49%的癌症样本队列中存在HPV和EBV;47%的样本对两种癌病毒均呈阳性。仅在15%的样本中检测到mmtv样病毒，与临床病理特征无显著关联。这三种癌病毒在14%的病例中同时存在;这些病毒的共同存在与临床病理特征之间没有明显的联系。结论:尽管存在癌病毒，但需要进一步的研究来了解它们在人类乳腺癌发生中的相互作用。

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Incidence of HPVs, EBV, and MMTV-Like Virus in Breast Cancer in Qatar

Introduction: Human papillomaviruses (HPVs), Epstein-Barr virus (EBV), and mouse mammary tumor virus-like virus (MMTV-like virus) can be present and contribute to breast cancer development and progression. However, the role of these oncoviruses and their crosstalk in breast cancer is still unclear. Methods: We explored the co-presence of high-risk HPVs, EBV, and MMTV-like virus in 74 breast cancer samples from Qatar using PCR. Results: We found the presence of HPV and EBV in 65% and 49% of our cancer sample cohorts; 47% of the samples are positive for both oncoviruses. The MMTV-like virus alone was detected in 15% of the samples with no significant association with clinicopathological features. The three oncoviruses were co-present in 14% of the cases; no significant association was noted between the co-presence of these viruses and the clinicopathological features. Conclusion: Despite the presence of the oncoviruses, additional studies are necessary to understand their interactions in human breast carcinogenesis.

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来源期刊

Intervirology 医学-病毒学

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Intervirology'' covers progress in both basic and clinical virus research, and aims to provide a forum for the various disciplines within virology. Issues publishing original papers alternate with thematic issues, focusing on clearly defined topics. This thematic concentration serves to make timely reviews, research reports and controversy easily accessible to both specialists in the field and those who want to keep track of the latest developments outside their own area of interest. In addition to original papers, regular issues publish short communications and letters to the editor to provide readers with a forum for the exchange of ideas and comments. The scope encompasses work on the molecular biology of human and animal viruses, including genome organization and regulation, and the structure and function of viral proteins. The pathogenesis, immunology, diagnosis, epidemiology, prophylaxis and therapy of viral diseases are considered.