{"title":"重点介绍了纸基微流体装置在法医调查中的应用","authors":"Abhimanyu Harshey, Alok Kumar, Akash Kumar, Tanurup Das, Kriti Nigam, Ankit Srivastava","doi":"10.1007/s10404-023-02674-z","DOIUrl":null,"url":null,"abstract":"<div><p>It is a well-established fact that legally sound evidences are required to prove or disprove any criminal activity. When a particular activity occurs, it leaves a trace out of mutual contact and failure to detect that trace proves the activity did not occur. To enhance the capabilities of the justice system in evaluating evidence, researchers are continuously engaged in the development of novel analytical techniques which provide scientific methodologies for effectively assessing and interpreting the evidence associated with criminal activities. Among the several devices available, paper-based microanalytical devices (μPADs) have attracted the interest of forensic scientists/experts in recent years. These devices are designed with microchannels to which dedicated reagents are added for promoting selective reactions. As a result, they offer a practical and convenient solution for on-site detection of physical evidence, providing ready-to-use capabilities for forensic investigations. This does not only help the investigators in collection of legally sound evidences but also open avenues in apprehending the potential offender who might be present in the scene by detecting the traces. μPADs are inexpensive, simpler to operate, require less chemical consumption, portable, and provides results visible to naked eye. Furthermore, with the aid of digital scoring of color intensity, semi-quantitative results can be generated. This review explains current state of applications and operating chemistry of µPADs involved in analysis of evidences of forensic interest such as explosives, gunshot residue, drugs of abuse, pesticides, body fluids, and estimation of time since death. Furthermore, the research gaps in the domain and viability of future trends for the application of µPADs in forensic science are also presented.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Focusing the intervention of paper-based microfluidic devices for the forensic investigative purposes\",\"authors\":\"Abhimanyu Harshey, Alok Kumar, Akash Kumar, Tanurup Das, Kriti Nigam, Ankit Srivastava\",\"doi\":\"10.1007/s10404-023-02674-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>It is a well-established fact that legally sound evidences are required to prove or disprove any criminal activity. When a particular activity occurs, it leaves a trace out of mutual contact and failure to detect that trace proves the activity did not occur. To enhance the capabilities of the justice system in evaluating evidence, researchers are continuously engaged in the development of novel analytical techniques which provide scientific methodologies for effectively assessing and interpreting the evidence associated with criminal activities. Among the several devices available, paper-based microanalytical devices (μPADs) have attracted the interest of forensic scientists/experts in recent years. These devices are designed with microchannels to which dedicated reagents are added for promoting selective reactions. As a result, they offer a practical and convenient solution for on-site detection of physical evidence, providing ready-to-use capabilities for forensic investigations. This does not only help the investigators in collection of legally sound evidences but also open avenues in apprehending the potential offender who might be present in the scene by detecting the traces. μPADs are inexpensive, simpler to operate, require less chemical consumption, portable, and provides results visible to naked eye. Furthermore, with the aid of digital scoring of color intensity, semi-quantitative results can be generated. This review explains current state of applications and operating chemistry of µPADs involved in analysis of evidences of forensic interest such as explosives, gunshot residue, drugs of abuse, pesticides, body fluids, and estimation of time since death. Furthermore, the research gaps in the domain and viability of future trends for the application of µPADs in forensic science are also presented.</p></div>\",\"PeriodicalId\":706,\"journal\":{\"name\":\"Microfluidics and Nanofluidics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2023-08-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microfluidics and Nanofluidics\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10404-023-02674-z\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INSTRUMENTS & INSTRUMENTATION\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microfluidics and Nanofluidics","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s10404-023-02674-z","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INSTRUMENTS & INSTRUMENTATION","Score":null,"Total":0}
Focusing the intervention of paper-based microfluidic devices for the forensic investigative purposes
It is a well-established fact that legally sound evidences are required to prove or disprove any criminal activity. When a particular activity occurs, it leaves a trace out of mutual contact and failure to detect that trace proves the activity did not occur. To enhance the capabilities of the justice system in evaluating evidence, researchers are continuously engaged in the development of novel analytical techniques which provide scientific methodologies for effectively assessing and interpreting the evidence associated with criminal activities. Among the several devices available, paper-based microanalytical devices (μPADs) have attracted the interest of forensic scientists/experts in recent years. These devices are designed with microchannels to which dedicated reagents are added for promoting selective reactions. As a result, they offer a practical and convenient solution for on-site detection of physical evidence, providing ready-to-use capabilities for forensic investigations. This does not only help the investigators in collection of legally sound evidences but also open avenues in apprehending the potential offender who might be present in the scene by detecting the traces. μPADs are inexpensive, simpler to operate, require less chemical consumption, portable, and provides results visible to naked eye. Furthermore, with the aid of digital scoring of color intensity, semi-quantitative results can be generated. This review explains current state of applications and operating chemistry of µPADs involved in analysis of evidences of forensic interest such as explosives, gunshot residue, drugs of abuse, pesticides, body fluids, and estimation of time since death. Furthermore, the research gaps in the domain and viability of future trends for the application of µPADs in forensic science are also presented.
期刊介绍:
Microfluidics and Nanofluidics is an international peer-reviewed journal that aims to publish papers in all aspects of microfluidics, nanofluidics and lab-on-a-chip science and technology. The objectives of the journal are to (1) provide an overview of the current state of the research and development in microfluidics, nanofluidics and lab-on-a-chip devices, (2) improve the fundamental understanding of microfluidic and nanofluidic phenomena, and (3) discuss applications of microfluidics, nanofluidics and lab-on-a-chip devices. Topics covered in this journal include:
1.000 Fundamental principles of micro- and nanoscale phenomena like,
flow, mass transport and reactions
3.000 Theoretical models and numerical simulation with experimental and/or analytical proof
4.000 Novel measurement & characterization technologies
5.000 Devices (actuators and sensors)
6.000 New unit-operations for dedicated microfluidic platforms
7.000 Lab-on-a-Chip applications
8.000 Microfabrication technologies and materials
Please note, Microfluidics and Nanofluidics does not publish manuscripts studying pure microscale heat transfer since there are many journals that cover this field of research (Journal of Heat Transfer, Journal of Heat and Mass Transfer, Journal of Heat and Fluid Flow, etc.).