青光眼患者滴注抗高血压药物期间的不适和眼表状况

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
D. A. Dorofeev, Alexey A. Antonov, A. V. Gorobets, E. V. Kirilik, Alexandra K. Safronova, A. Sinitsky, O. Pozdeeva, Yu. M. Shatrova, A. Z. Tsyganov
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引用次数: 0

摘要

背景——在降压治疗的背景下,干眼综合征(DES)表现频率的增加会导致治疗依从性的降低。在重新配制无防腐剂的碳酸酐酶抑制剂(CAI)制剂(添加了苯甲酸钠)后,患者在滴注过程中出现烧灼感的抱怨变得更加频繁,这就是我们进行研究的原因。目的:评价苯甲酸钠在青光眼局部降压治疗中对DES疗程的影响。方法和结果:第一组21眼青光眼患者接受降压治疗,第二组20眼疑似青光眼患者未接受降压治疗。患者接受了标准的诊断方法和眼表状况检查:泪液破裂时间测试(sensu-Norn)、Schirmer测试、赖氨酸绿活体染色,以及基于眼表疾病指数(OSDI)问卷的调查。当用含苯甲酸钠的CAI代替联合治疗中的不含防腐剂的CAI时,治疗四周后眼压没有发生统计学上显著的变化(p>0.05)。在两组中,表征眼表状况的指标在观察期内没有统计学上显著变化。结论:用苯甲酸钠联合应用无防腐剂CAI代替CAI治疗青光眼,眼压变化无统计学意义。眼表状况在一个月的观察中没有统计学上的显著变化。灌输不适与制剂的pH值无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Discomfort During Instillation Of Antihypertensives And Ocular Surface Condition In Glaucoma Patients
Background — An increase in the frequency of manifestations of dry eye syndrome (DES), against the background of hypotensive therapy, leads to a decrease in treatment adherence. After reformulation in the composition of a preservative-free preparation of a carbonic anhydrase inhibitor (CAI) (sodium benzoate was added), patient complaints of burning sensation during instillation became more frequent, which was the reason for our study. Objective — To evaluate the effect of sodium benzoate on the course of DES during local hypotensive therapy of glaucoma. Methods and Results — Group 1 consisted of 21 eyes with glaucoma receiving hypotensive therapy, Group 2 (20 eyes) included patients with suspected glaucoma not receiving therapy. Patients underwent standard diagnostic methods and examination of the ocular surface condition: tear break-up time test sensu Norn, Schirmer test, vital staining with lissamine green, and a survey based on the Ocular Surface Disease Index (OSDI) questionnaire. When a preservative-free CAI in combination therapy was replaced with the CAI containing sodium benzoate, no statistically significant change in IOP occurred after four weeks of treatment (p> 0.05). In both groups, the indicators characterizing the ocular surface condition did not change statistically significantly over the observation period. Conclusion — Replacement of preservative-free CAI in combination therapy of glaucoma with CAI with sodium benzoate does not lead to statistically significant changes in intraocular pressure. The ocular surface condition does not change statistically significantly over a month of observation. Instillation discomfort is not related to the pH of the preparation.
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来源期刊
Russian Open Medical Journal
Russian Open Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
0.90
自引率
0.00%
发文量
39
期刊介绍: Russian Open Medical Journal (RusOMJ) (ISSN 2304-3415) is an international peer reviewed open access e-journal. The website is updated quarterly with the RusOMJ’s latest original research, clinical studies, case reports, reviews, news, and comment articles. This Journal devoted to all field of medicine. All the RusOMJ’s articles are published in full on www.romj.org with open access and no limits on word counts. Our mission is to lead the debate on health and to engage, inform, and stimulate doctors, researchers, and other health professionals in ways that will improve outcomes for patients. The RusOMJ team is based mainly in Saratov (Russia), although we also have editors elsewhere in Russian and in other countries.
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