多细胞脂质隔室从多孔聚合物结构自发和驱动生长到毫米大小**

IF 3.1 Q2 CHEMISTRY, MULTIDISCIPLINARY
Prof. Shin-ichiro M. Nomura, Ryo Shimizu, Dr. Richard James Archer, Dr. Gen Hayase, Prof. Taro Toyota, Prof. Richard Mayne, Prof. Andrew Adamatzky
{"title":"多细胞脂质隔室从多孔聚合物结构自发和驱动生长到毫米大小**","authors":"Prof. Shin-ichiro M. Nomura,&nbsp;Ryo Shimizu,&nbsp;Dr. Richard James Archer,&nbsp;Dr. Gen Hayase,&nbsp;Prof. Taro Toyota,&nbsp;Prof. Richard Mayne,&nbsp;Prof. Andrew Adamatzky","doi":"10.1002/syst.202200006","DOIUrl":null,"url":null,"abstract":"<p>This report describes a method to obtain multicellular shaped compartments made by lipids growing from a sponge-like porous structure. Each compartment is several tens of micrometers in diameter and separated by membranes comprised of phospholipid and amphipathic molecules. The multi-compartment structure spontaneously grew to a millimeter scale, driven by an ionic concentration difference between the interior and exterior environments of the sponge. These compartments can also easily incorporate hydrophilic species as a well as smaller materials such as liposomes. Additionally, we showed that mechanical squeezing of the sponge was also effective in producing multicellular bodies. These simple methods to obtain large-scale multicellular compartment of lipid membrane will help future designs and trials of chemical communications on artificial cells.</p>","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202200006","citationCount":"3","resultStr":"{\"title\":\"Spontaneous and Driven Growth of Multicellular Lipid Compartments to Millimeter Size from Porous Polymer Structures**\",\"authors\":\"Prof. Shin-ichiro M. Nomura,&nbsp;Ryo Shimizu,&nbsp;Dr. Richard James Archer,&nbsp;Dr. Gen Hayase,&nbsp;Prof. Taro Toyota,&nbsp;Prof. Richard Mayne,&nbsp;Prof. Andrew Adamatzky\",\"doi\":\"10.1002/syst.202200006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>This report describes a method to obtain multicellular shaped compartments made by lipids growing from a sponge-like porous structure. Each compartment is several tens of micrometers in diameter and separated by membranes comprised of phospholipid and amphipathic molecules. The multi-compartment structure spontaneously grew to a millimeter scale, driven by an ionic concentration difference between the interior and exterior environments of the sponge. These compartments can also easily incorporate hydrophilic species as a well as smaller materials such as liposomes. Additionally, we showed that mechanical squeezing of the sponge was also effective in producing multicellular bodies. These simple methods to obtain large-scale multicellular compartment of lipid membrane will help future designs and trials of chemical communications on artificial cells.</p>\",\"PeriodicalId\":72566,\"journal\":{\"name\":\"ChemSystemsChem\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2022-04-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202200006\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ChemSystemsChem\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/syst.202200006\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemSystemsChem","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/syst.202200006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 3

摘要

本报告描述了一种方法,以获得多细胞形状的室由脂类生长的海绵状多孔结构。每个隔室直径几十微米,由磷脂和两亲分子组成的膜隔开。在海绵内部和外部环境的离子浓度差异的驱动下,多室结构自发地生长到毫米尺度。这些隔室也可以很容易地纳入亲水性物质以及较小的物质,如脂质体。此外,我们发现海绵的机械挤压也有效地产生多细胞体。这些获得大规模多细胞脂膜隔室的简单方法将有助于未来在人造细胞上进行化学通讯的设计和试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Spontaneous and Driven Growth of Multicellular Lipid Compartments to Millimeter Size from Porous Polymer Structures**

Spontaneous and Driven Growth of Multicellular Lipid Compartments to Millimeter Size from Porous Polymer Structures**

This report describes a method to obtain multicellular shaped compartments made by lipids growing from a sponge-like porous structure. Each compartment is several tens of micrometers in diameter and separated by membranes comprised of phospholipid and amphipathic molecules. The multi-compartment structure spontaneously grew to a millimeter scale, driven by an ionic concentration difference between the interior and exterior environments of the sponge. These compartments can also easily incorporate hydrophilic species as a well as smaller materials such as liposomes. Additionally, we showed that mechanical squeezing of the sponge was also effective in producing multicellular bodies. These simple methods to obtain large-scale multicellular compartment of lipid membrane will help future designs and trials of chemical communications on artificial cells.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
7.00
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信