生物流体的傅立叶变换红外光谱:一种实用的方法

A. G. Theakstone, Christopher Rinaldi, Holly J. Butler, James M. Cameron, L. Confield, Samantha H. Rutherford, A. Sala, Sayali Sangamnerkar, M. Baker
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引用次数: 25

摘要

生物流体光谱学是临床研究领域的一项新兴技术,它提供了一种从易于获取的样本中提取诊断和观测信息的简单方法。红外光谱法非常适合分析各种生物流体样本,包括血液及其衍生物,因为它具有灵活的采样模式和对细微生物变化的高灵敏度。随着技术向临床的发展,影响临床翻译成功的因素越来越明显。在这里,我们提供了一个有效的生物流体光谱学研究设计教程,讨论了样品和仪器参数以及临床注意事项。目的是介绍目前对生物流体光谱学领域临床翻译的理解,并促进其他临床应用向临床发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fourier‐transform infrared spectroscopy of biofluids: A practical approach
Biofluid spectroscopy is an emerging technology in the field of clinical investigation, providing a simple way to extract diagnostic and observational information from easy to acquire samples. Infrared spectroscopy is well suited to analyse a large range of biofluid samples, including blood and its derivatives, due to flexible sampling modes and high sensitivity to subtle biological changes. As the technology advances towards the clinic, factors influencing successful clinical translation are becoming apparent. Here, we provide a tutorial for effective biofluid spectroscopy study design, discussing sample and instrument parameters, as well as clinical considerations. The aim is to present the current understanding of clinical translation in the field of biofluid spectroscopy, and to facilitate other clinical applications to advance to the clinic.
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