Hyperuricemia - As a Pathogenetic and Independent Risk Factor in Relation to the Metabolic Syndrome

Abstract Introduction: The Metabolic Syndrome is considered at present as one of the most important causes of mortality and morbidity at world level. Even if the uric acid is not part of any definition of the Metabolic Syndrome, the actual studies have shown strong associations between uric acid concentration and the Metabolic Syndrome or its components, the role of Uric Acid within the Metabolic Syndrome (MS) being increasingly investigated. Aims: We have analyzed recently published data that show the importance of hyperuricemia in MS, Cardiovascular Diseases, Chronic Kidney Disease. Conclusions: Uric Acid (UA) is a central player in MS progression and in cardiorenal pathology, which is why a multidisciplinary approach and a correct treatment are required, in order to obtain multiple benefits and, possibly, in the future, new therapeutic guidelines in approaching MS.