明胶支架——再生治疗的直观支撑结构

IF 4.7 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL
Adib Bin Rashid , Nazmir-Nur Showva , Md Enamul Hoque
{"title":"明胶支架——再生治疗的直观支撑结构","authors":"Adib Bin Rashid ,&nbsp;Nazmir-Nur Showva ,&nbsp;Md Enamul Hoque","doi":"10.1016/j.cobme.2023.100452","DOIUrl":null,"url":null,"abstract":"<div><p>Advanced regenerative therapy aims to repair pathologically damaged tissue by cell transplantation in conjunction with supporting scaffolds. Gelatin-based scaffolds have attracted much attention in recent years due to their great bio-affinity that encourages the regeneration of tissues. Nowadays, by strengthening gelatin-based systems, cutting-edge methods like 3D bioprinting, freeze-drying, microfluidics and gelatin functionalization have shown excellent mimicry of natural tissue. The fabrication of porous gelatin-based scaffolds for wider tissue engineering applications including skin, cartilage, bone, liver, and cardiovascular is reviewed in this work. Additionally, the crosslinking procedures and the physicochemical characteristics of the gelatin-based scaffolds are also studied. Now, gelatin is considered one of the highest potential biomaterials for impending trends in which the gelatin-based scaffolds are used as a support structure for regenerative therapy.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"26 ","pages":"Article 100452"},"PeriodicalIF":4.7000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Gelatin-based scaffolds: An intuitive support structure for regenerative therapy\",\"authors\":\"Adib Bin Rashid ,&nbsp;Nazmir-Nur Showva ,&nbsp;Md Enamul Hoque\",\"doi\":\"10.1016/j.cobme.2023.100452\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Advanced regenerative therapy aims to repair pathologically damaged tissue by cell transplantation in conjunction with supporting scaffolds. Gelatin-based scaffolds have attracted much attention in recent years due to their great bio-affinity that encourages the regeneration of tissues. Nowadays, by strengthening gelatin-based systems, cutting-edge methods like 3D bioprinting, freeze-drying, microfluidics and gelatin functionalization have shown excellent mimicry of natural tissue. The fabrication of porous gelatin-based scaffolds for wider tissue engineering applications including skin, cartilage, bone, liver, and cardiovascular is reviewed in this work. Additionally, the crosslinking procedures and the physicochemical characteristics of the gelatin-based scaffolds are also studied. Now, gelatin is considered one of the highest potential biomaterials for impending trends in which the gelatin-based scaffolds are used as a support structure for regenerative therapy.</p></div>\",\"PeriodicalId\":36748,\"journal\":{\"name\":\"Current Opinion in Biomedical Engineering\",\"volume\":\"26 \",\"pages\":\"Article 100452\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2023-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Biomedical Engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468451123000089\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Biomedical Engineering","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468451123000089","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 5

摘要

先进的再生疗法旨在通过细胞移植结合支架修复病理损伤的组织。近年来,明胶基支架因其具有促进组织再生的生物亲和性而受到广泛关注。如今,通过强化以明胶为基础的系统,3D生物打印、冷冻干燥、微流体和明胶功能化等尖端方法已经显示出对天然组织的出色模仿。本文综述了多孔明胶基支架在组织工程中的广泛应用,包括皮肤、软骨、骨骼、肝脏和心血管。此外,还研究了明胶基支架的交联过程和理化特性。现在,明胶被认为是最有潜力的生物材料之一,在即将到来的趋势中,明胶基支架被用作再生治疗的支持结构。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gelatin-based scaffolds: An intuitive support structure for regenerative therapy

Advanced regenerative therapy aims to repair pathologically damaged tissue by cell transplantation in conjunction with supporting scaffolds. Gelatin-based scaffolds have attracted much attention in recent years due to their great bio-affinity that encourages the regeneration of tissues. Nowadays, by strengthening gelatin-based systems, cutting-edge methods like 3D bioprinting, freeze-drying, microfluidics and gelatin functionalization have shown excellent mimicry of natural tissue. The fabrication of porous gelatin-based scaffolds for wider tissue engineering applications including skin, cartilage, bone, liver, and cardiovascular is reviewed in this work. Additionally, the crosslinking procedures and the physicochemical characteristics of the gelatin-based scaffolds are also studied. Now, gelatin is considered one of the highest potential biomaterials for impending trends in which the gelatin-based scaffolds are used as a support structure for regenerative therapy.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Current Opinion in Biomedical Engineering
Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
2.60%
发文量
59
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信