N-(1-([1,2,4]三唑[3,4-b][1,3,4]噻二唑-6-氨基)-2,2,2-三氯乙基)羧酰胺的合成及光谱特性

IF 1.3 3区化学 Q3 CHEMISTRY, ORGANIC

Heterocyclic Communications Pub Date : 2019-01-01 DOI:10.1515/hc-2019-0020

Pavlo V. Zadorozhnii, Ihor O. Pokotylo, V. Kiselev, A. V. Kharchenko, Oxana V. Okhtina

引用次数: 3

摘要

摘要基于现成的N-（2,2,2-三氯-1-羟乙基）甲酰胺、N-（2,,2-三氯-1-（3-（3-巯基-4H-1,2,4-三唑-4-基）硫脲基）乙基）甲酰胺，在过量HgO的影响下，脱氢硫化反应导致N-（1-（[1,2,4]三唑并[3,4-b][1,3,4]噻二唑-6-基氨基）-2,2,2-三氯苯甲酰胺的形成。反应在沸腾的冰醋酸中进行1-1.5小时。环化产物以42-62%的产率获得，并且容易从反应混合物中分离。通过复杂的光谱研究证实了所有合成化合物的结构。

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Synthesis and spectral characteristics of N-(1-([1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-ylamino)-2,2,2-trichloroethyl)carboxamides

Abstract Based on readily available N-(2,2,2-trichloro-1-hydroxyethyl)carboxamides, N-(2,2,2-trichloro-1-(3-(3-mercapto-4H-1,2,4-triazol-4-yl)thioureido)ethyl) carboxamides, dehydrosulfurization–under the influence of excess HgO–led to the formation of N-(1-([1,2,4] triazolo[3,4-b][1,3,4]thiadiazol-6-ylamino)-2,2,2-trichloroethyl)carboxamides. The reaction was carried out in boiling glacial acetic acid for 1-1.5 hours. The cyclization products were obtained in 42-62% yields and easily isolated from the reaction mixture. The structure of all synthesized compounds was confirmed by complex spectral studies.

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来源期刊

Heterocyclic Communications 化学-有机化学

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

1.4 months

期刊介绍： Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.