新生儿坏死性小肠结肠炎的神经系统后果

IF 2.3 4区医学 Q2 DEVELOPMENTAL BIOLOGY

Developmental Neuroscience Pub Date : 2022-06-13 DOI:10.1159/000525378

Jonathan A. Berken, Jill Chang

{"title":"新生儿坏死性小肠结肠炎的神经系统后果","authors":"Jonathan A. Berken, Jill Chang","doi":"10.1159/000525378","DOIUrl":null,"url":null,"abstract":"Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease of the premature infant with high mortality and morbidity. Children who survive NEC have been shown to demonstrate neurodevelopmental delay, with significantly worse outcomes than from prematurity alone. The pathways leading to NEC-associated neurological impairments remain unclear, limiting the development of preventative and protective strategies. This review aims to summarize the existing clinical and experimental studies related to NEC-associated brain injury. We describe the current epidemiology of NEC, reported long-term neurodevelopmental outcomes among survivors, and proposed pathogenesis of brain injury in NEC. Highlighted are the potential connections between hypoxia-ischemia, nutrition, infection, gut inflammation, and the developing brain in NEC.","PeriodicalId":50585,"journal":{"name":"Developmental Neuroscience","volume":"44 1","pages":"295 - 308"},"PeriodicalIF":2.3000,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"9","resultStr":"{\"title\":\"Neurologic Consequences of Neonatal Necrotizing Enterocolitis\",\"authors\":\"Jonathan A. Berken, Jill Chang\",\"doi\":\"10.1159/000525378\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease of the premature infant with high mortality and morbidity. Children who survive NEC have been shown to demonstrate neurodevelopmental delay, with significantly worse outcomes than from prematurity alone. The pathways leading to NEC-associated neurological impairments remain unclear, limiting the development of preventative and protective strategies. This review aims to summarize the existing clinical and experimental studies related to NEC-associated brain injury. We describe the current epidemiology of NEC, reported long-term neurodevelopmental outcomes among survivors, and proposed pathogenesis of brain injury in NEC. Highlighted are the potential connections between hypoxia-ischemia, nutrition, infection, gut inflammation, and the developing brain in NEC.\",\"PeriodicalId\":50585,\"journal\":{\"name\":\"Developmental Neuroscience\",\"volume\":\"44 1\",\"pages\":\"295 - 308\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2022-06-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Developmental Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000525378\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DEVELOPMENTAL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Developmental Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000525378","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}

引用次数: 9

摘要

坏死性小肠结肠炎(NEC)是一种严重的早产儿胃肠道疾病，死亡率和发病率都很高。NEC存活下来的儿童表现出神经发育迟缓，其结果明显比单纯的早产更糟糕。导致nec相关神经损伤的途径尚不清楚，限制了预防和保护策略的发展。本文就nec相关脑损伤的临床和实验研究进行综述。我们描述了NEC的当前流行病学，报告了幸存者的长期神经发育结果，并提出了NEC脑损伤的发病机制。重点是缺氧缺血、营养、感染、肠道炎症和NEC脑发育之间的潜在联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Neurologic Consequences of Neonatal Necrotizing Enterocolitis

Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease of the premature infant with high mortality and morbidity. Children who survive NEC have been shown to demonstrate neurodevelopmental delay, with significantly worse outcomes than from prematurity alone. The pathways leading to NEC-associated neurological impairments remain unclear, limiting the development of preventative and protective strategies. This review aims to summarize the existing clinical and experimental studies related to NEC-associated brain injury. We describe the current epidemiology of NEC, reported long-term neurodevelopmental outcomes among survivors, and proposed pathogenesis of brain injury in NEC. Highlighted are the potential connections between hypoxia-ischemia, nutrition, infection, gut inflammation, and the developing brain in NEC.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Developmental Neuroscience 医学-发育生物学

CiteScore

4.00

自引率

3.40%

发文量

审稿时长

>12 weeks

期刊介绍： ''Developmental Neuroscience'' is a multidisciplinary journal publishing papers covering all stages of invertebrate, vertebrate and human brain development. Emphasis is placed on publishing fundamental as well as translational studies that contribute to our understanding of mechanisms of normal development as well as genetic and environmental causes of abnormal brain development. The journal thus provides valuable information for both physicians and biologists. To meet the rapidly expanding information needs of its readers, the journal combines original papers that report on progress and advances in developmental neuroscience with concise mini-reviews that provide a timely overview of key topics, new insights and ongoing controversies. The editorial standards of ''Developmental Neuroscience'' are high. We are committed to publishing only high quality, complete papers that make significant contributions to the field.