一种新的大脑专用PET扫描仪，具有4D检测器信息

IF 1.2 Q3 Computer Science

Bio-Algorithms and Med-Systems Pub Date : 2022-12-01 DOI:10.2478/bioal-2022-0083

A. Gonzalez-Montoro, J. Barberá, D. Sanchez, Alvaro Mondejar, M. Freire, Karel Diaz, Alejandro Lucero, S. Jiménez-Serrano, J. Alamo, C. Morera-Ballester, J. Barrio, N. Cucarella, V. Ilisie, L. Moliner, C. Valladares, Antonio J. Gonzalez, John O. Prior, J. Benlloch

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引用次数: 5

摘要

在这篇文章中，我们介绍了一种用于研究人脑的高灵敏度器官特异性正电子发射断层扫描（PET）系统的几何设计和初步结果。该系统名为4D-PET，由于其预期的高灵敏度、高3D空间分辨率，以及通过包括精确的光子飞行时间（TOF）信息，提高了信噪比（SNR），将允许对大脑研究进行精确成像。4D-PET系统采用了基于晶体板（半单片）的创新探测器设计，能够实现精确的3D光子碰撞定位（包括光子相互作用深度（DOI）测量），同时为探测器提供光子到达时间的精确确定。该探测器包括一个新颖的读出系统，该系统以4:1的比例减少了探测器信号的数量，从而降低了复杂性和成本。模拟输出信号被馈送到TOFPET2 ASIC（PETsys），用于可扩展性目的。本手稿报告了4D-PET探测器的评估，获得了<1.6 mm（像素化轴）、2.7±0.5 mm（单片轴）和3.4±1.1（DOI轴）mm的最佳3D分辨率值；359±7ps符合时间分辨率（CTR）；10.2±1.5%的能量分辨率；在扫描器中心的灵敏度为16.2%（模拟）。此外，还提供了4D-PET架构（包括320个探测器）的全面描述、其机械组件的一些图片以及对预期图像质量的模拟。

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A new brain dedicated PET scanner with 4D detector information

In this article, we present the geometrical design and preliminary results of a high sensitivity organ-specific Positron Emission Tomography (PET) system dedicated to the study of the human brain. The system, called 4D-PET, will allow accurate imaging of brain studies due to its expected high sensitivity, high 3D spatial resolution and, by including precise photon time of flight (TOF) information, a boosted signal-to-noise ratio (SNR). The 4D-PET system incorporates an innovative detector design based on crystal slabs (semi-monolithic) that enables accurate 3D photon impact positioning (including photon Depth of Interaction (DOI) measurement), while providing a precise determination of the photon arrival time to the detector. The detector includes a novel readout system that reduces the number of detector signals in a ratio of 4:1 thus, alleviating complexity and cost. The analog output signals are fed to the TOFPET2 ASIC (PETsys) for scalability purposes. The present manuscript reports the evaluation of the 4D-PET detector, achieving best values 3D resolution values of <1.6 mm (pixelated axis), 2.7±0.5 mm (monolithic axis) and 3.4±1.1 (DOI axis) mm; 359 ± 7 ps coincidence time resolution (CTR); 10.2±1.5 % energy resolution; and sensitivity of 16.2% at the center of the scanner (simulated). Moreover, a comprehensive description of the 4D-PET architecture (that includes 320 detectors), some pictures of its mechanical assembly, and simulations on the expected image quality are provided.

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来源期刊

Bio-Algorithms and Med-Systems MATHEMATICAL & COMPUTATIONAL BIOLOGY-

CiteScore

3.80

自引率

0.00%

发文量

期刊介绍： The journal Bio-Algorithms and Med-Systems (BAMS), edited by the Jagiellonian University Medical College, provides a forum for the exchange of information in the interdisciplinary fields of computational methods applied in medicine, presenting new algorithms and databases that allows the progress in collaborations between medicine, informatics, physics, and biochemistry. Projects linking specialists representing these disciplines are welcome to be published in this Journal. Articles in BAMS are published in English. Topics Bioinformatics Systems biology Telemedicine E-Learning in Medicine Patient''s electronic record Image processing Medical databases.