益生元和维生素对儿童肠道健康的饮食干预

IF 1 Q4 FOOD SCIENCE & TECHNOLOGY
Deepti Kaushal, G. Kalsi
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引用次数: 1

摘要

目的肠道健康对儿童生长发育具有多方面的影响。饮食是肠道健康的主要调节因素,本研究旨在假设膳食中益生元和维生素的补充是否会影响健康儿童的肠道环境。设计/方法/方法进行了一项双盲安慰剂对照试验,将8-13岁的儿童平行分配到安慰剂组或试验组。试验组在对照组基础上补充1.5 g含益生元和维生素的制剂,在安慰剂基础上补充1.5 g麦芽糖糊精。四周后,在儿童粪便中评估对肠道健康标志物(即有益微生物和肠道完整性标志物,如分泌免疫球蛋白A [sIgA]和钙保护蛋白浓度)的影响。结果:4周后,与安慰剂相比,试验组粪便双歧杆菌计数显著增加17.1% (p = 0.04)。与安慰剂相比,试验组粪便钙保护蛋白浓度显著降低(20%)(p = 0.01)。此外,与基线浓度相比,试验组粪便sIgA和乳酸菌浓度有显著改善(p分别= 0.01和0.001)。研究局限性/意义本研究表明,益生元(和维生素)干预可能通过积极调节肠道健康标志物来影响儿童的健康结果。原创性/价值证明益生元和维生素对学龄儿童肠道健康的功效的研究有限。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dietary intervention of prebiotics and vitamins on gut health of children
Purpose Gut health has multidimensional impact on childhood growth and development. Diet being the major modulator of gut health, this study aims to hypothesize if supplementation of dietary prebiotics and vitamins can impact gut environment of healthy children. Design/methodology/approach A double-blind placebo-controlled trial was conducted with parallel allocation of children 8–13 years of age to placebo or test group. Test group was supplemented with 1.5 g of formulation comprising prebiotics and vitamins, and to placebo, maltodextrin (1.5 g) was supplemented. After four weeks, the effect on markers of gut health (i.e. beneficial microbes, and gut integrity markers such as secretory Immunoglobulin A [sIgA] and calprotectin concentration) was evaluated in feces of children. Findings Significant increase of 17.1% in fecal bifidobacteria counts (p = 0.04) was observed in the test group compared to placebo after four weeks. Also, fecal calprotectin concentration decreased (20%) significantly (p = 0.01) in test group compared to placebo. In addition, the test group showed significant improvement in fecal sIgA and lactobacilli compared to baseline concentration (p = 0.01 and 0.001, respectively). Research limitations/implications This study demonstrates that prebiotic (and vitamin) intervention may influence health outcomes in children by positively modulating markers of gut health. Originality/value There are limited studies demonstrating the efficacy of prebiotic and vitamins on gut health of school age children.
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来源期刊
Nutrition & Food Science
Nutrition & Food Science FOOD SCIENCE & TECHNOLOGY-
CiteScore
2.80
自引率
8.30%
发文量
85
期刊介绍: Nutrition & Food Science* (NFS) is an international, double blind peer-reviewed journal offering accessible and comprehensive coverage of food, beverage and nutrition research. The journal draws out the practical and social applications of research, demonstrates best practice through applied research and case studies and showcases innovative or controversial practices and points of view. The journal is an invaluable resource to inform individuals, organisations and the public on modern thinking, research and attitudes to food science and nutrition. NFS welcomes empirical and applied research, viewpoint papers, conceptual and technical papers, case studies, meta-analysis studies, literature reviews and general reviews which take a scientific approach to the following topics: -Attitudes to food and nutrition -Healthy eating/ nutritional public health initiatives, policies and legislation -Clinical and community nutrition and health (including public health and multiple or complex co-morbidities) -Nutrition in different cultural and ethnic groups -Nutrition during pregnancy, lactation, childhood, and young adult years -Nutrition for adults and older people -Nutrition in the workplace -Nutrition in lower and middle income countries (incl. comparisons with higher income countries) -Food science and technology, including food processing and microbiological quality -Genetically engineered foods -Food safety / quality, including chemical, physical and microbiological analysis of how these aspects effect health or nutritional quality of foodstuffs
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