紫外光谱法同时测定成品剂型中吡喹酮和阿维菌素的一阶导数法的建立与验证

Q4 Pharmacology, Toxicology and Pharmaceutics

INDIAN DRUGS Pub Date : 2023-05-28 DOI:10.53879/id.60.05.12653

Brijesh K. Dasvani, Avani P. Khristi

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引用次数: 0

摘要

本研究以甲醇为增溶剂，对吡喹酮、阿维菌素等水溶性较差的药物进行增溶。建立了用一阶导数法同时测定吡喹酮和阿维菌素原料药及其复方剂型的紫外分光光度法。该方法以甲醇为共同溶剂，所选分析吡喹酮和阿维菌素的λmax分别在248 nm(阿维菌素的ZCP)和274 nm(吡喹酮的ZCP)处。吡喹酮在25 ~ 150µg mL-1范围内呈线性(r2 = 0.9984)， ABAM在1 ~ 11µg mL-1范围内呈线性(r2 = 0.9986)。测定的准确性和精密度符合ICH指南。该方法重现性好，回收率在规定的RSD范围内。将该方法应用于上市制剂。结果符合ICH指南的验收标准

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UV SPECTROSCOPIC METHOD DEVELOPMENT AND VALIDATION OF FIRST DERIVATIVE METHOD FOR SIMULTANEOUS ESTIMATION OF PRAZIQUANTEL AND ABAMECTIN IN FINISHED DOSAGE FORM

In the present investigation, methanol is employed as the solubilizing agent to solubilize poorly water soluble drugs such as praziquantel and abamectin. UV spectrophotometric method has been developed for simultaneous estimation of praziquantel and abamectin in bulk drug and in their combined pharmaceutical dosage form by first order derivative method. This method utilizes methanol as a common solvent and λmax of praziquantel and abamectin selected for analysis was found to be at 248 nm (at ZCP of abamectin) and 274 nm (at ZCP of praziquantel), respectively. Linearity was observed in the concentration range of 25-150 µg mL-1 for praziquantel (r2 = 0.9984) and 1-11 µg mL-1 for ABAM (r2 = 0.9986). The accuracy and precision were determined and found to comply with ICH guidelines. This method shows good reproducibility and recovery with % RSD in the desired range. Developed method was applied for marketed formulation. The results were found to be within acceptance criteria according to ICH guideline

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来源期刊

INDIAN DRUGS Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.30

自引率

0.00%

发文量