基于人脑生物电活动谱分析的生物年龄估计

IF 0.6 Q4 GERIATRICS & GERONTOLOGY
G. A. Shabanov, A. A. Rybchenko, Ye. A. Lugovaya, S. I. Vdovenko
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引用次数: 0

摘要

这项研究首次提供了一种基于大脑生物电活动的光谱分析来估计人类生物年龄的方法。我们开发了IDC分散指数,该指数是通过考虑大脑激活系统对外周组织和器官的背景神经营养影响的总减少来计算的。IDC指数对10至90岁健康人年龄以及癌症细胞分化程度G1–G4的依赖性接近线性。IDC指数从100到900个单位的增长可以检测到细胞功能紊乱和突变随年龄的积累。在细胞分化程度为G1至G4的癌症患者中,甚至更多的细胞突变导致IDC指数增加到3000个单位或更多。这些数据使我们能够在记录大脑生物电活动10分钟后估计一个人的生物年龄。当获得每个受试者的几个试验的平均数据时,估计准确性增加。该技术适用于癌症患者老年病学领域的科学研究、健康人群监测、风险群体揭示和治疗过程控制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Biological Age Estimation Based on the Spectral Analysis of the Bioelectrical Activity of the Human Brain

Biological Age Estimation Based on the Spectral Analysis of the Bioelectrical Activity of the Human Brain

This research offers a method of estimating human biological age based on the spectral analysis of the bioelectric activity of the brain for the first time. We have developed an IDC decentralization index, which is calculated by taking the total reduction of the background neurotrophic influences of the brain activating system on the peripheral tissues and organs into account. The obtained dependence of the IDC index on the age of healthy people at ages of 10 to 90, as well as on the degree of differentiation G1–G4 of cancer cells, was close to linear. The accumulation of cell malfunctions and mutations with age could be detected by the growth in the IDC index from 100 to 900 units. An even greater number of cell mutations in cancer patients with the G1 to G4 degree of cell differentiation resulted in the IDC index increasing to 3000 units or more. These data allowed us to estimate a person’s biological age after a 10-minute registration of the bioelectric activity of the brain. The estimation accuracy increased when averaged data were obtained for several trials of each subject. The technology is applicable in scientific research in the field of gerontology, monitoring healthy people, revealing risk groups, and controlling treatment process in cancer patients.

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来源期刊
Advances in Gerontology
Advances in Gerontology GERIATRICS & GERONTOLOGY-
CiteScore
0.80
自引率
16.70%
发文量
45
期刊介绍: Advances in Gerontology focuses on biomedical aspects of aging. The journal also publishes original articles and reviews on progress in the following research areas: demography of aging; molecular and physiological mechanisms of aging, clinical gerontology and geriatrics, prevention of premature aging, medicosocial aspects of gerontology, and behavior and psychology of the elderly.
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