Yu-zhu QU (瞿玉竹) , Li CHEN (陈丽) , Jing-ya CAO (曹静雅) , Pan ZHANG (张攀) , Yang-ke MAO (毛杨科) , Zi-lei TIAN (田子雷) , Yu-ke TENG (滕雨可) , Jing XIONG (熊静) , Tao YIN (尹涛) , Fang ZENG (曾芳)
{"title":"Real time central response of two classical acupuncture manipulations: Protocol for a randomized crossover fNIRS trial","authors":"Yu-zhu QU (瞿玉竹) , Li CHEN (陈丽) , Jing-ya CAO (曹静雅) , Pan ZHANG (张攀) , Yang-ke MAO (毛杨科) , Zi-lei TIAN (田子雷) , Yu-ke TENG (滕雨可) , Jing XIONG (熊静) , Tao YIN (尹涛) , Fang ZENG (曾芳)","doi":"10.1016/j.wjam.2022.12.004","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Reinforcing-reducing manipulations are a crucial part of acupuncture therapy. The reinforcing manipulation with heat sensation (RMHS) and the reducing manipulation by inducing cool sensation (RMCS) are two representative methods of reinforcing-reducing manipulations. This trial aims to investigate the characteristic of cerebral responses to these two typical acupuncture manipulations.</p></div><div><h3>Methods</h3><p><span>A total of 35 healthy participants will be included and receive acupuncture stimulation with RMHS and RMCS in a random order. The psychology, cognition, and body constitution of participants will be measured by the Self-rating Anxiety Scale (SAS), the Self-rating Depression Scale (SDS), the mindful attention awareness scale (MAAS), the Constitution in Chinese Medicine Questionnaire (CCMQ), and the needle sensation will be evaluated after each acupuncture stimulation immediately. The cerebral activity changes elicited by RMHS and RMCS will be detected by functional near-infrared spectroscopy (fNIRS) and analyzed with the general linear model-based activation and the channel-to-channel </span>functional connectivity.</p></div><div><h3>Discussion</h3><p>This trial will investigate the cerebral response induced by RMHS and RMCS by real-time fNIRS, so as to map the characteristics of the central responses’ patterns to these two manipulations and preliminarily explore the mechanism of traditional acupuncture manipulations.</p></div><div><h3>Trial registration</h3><p>Chinese Clinical Trials. gov Registry (ChiCTR2100051886).</p></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"33 2","pages":"Pages 168-175"},"PeriodicalIF":0.6000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Real-time cerebral response of two classic acupuncture manipulations: Protocol for a randomized crossover fNIRS trial 两种不同古典针刺手法的实时中枢整合特征研究:一项基于近红外光谱成像技术的随机交叉试验研究方案\",\"authors\":\"Yu-zhu QU (瞿玉竹) , Li CHEN (陈丽) , Jing-ya CAO (曹静雅) , Pan ZHANG (张攀) , Yang-ke MAO (毛杨科) , Zi-lei TIAN (田子雷) , Yu-ke TENG (滕雨可) , Jing XIONG (熊静) , Tao YIN (尹涛) , Fang ZENG (曾芳)\",\"doi\":\"10.1016/j.wjam.2022.12.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Reinforcing-reducing manipulations are a crucial part of acupuncture therapy. The reinforcing manipulation with heat sensation (RMHS) and the reducing manipulation by inducing cool sensation (RMCS) are two representative methods of reinforcing-reducing manipulations. This trial aims to investigate the characteristic of cerebral responses to these two typical acupuncture manipulations.</p></div><div><h3>Methods</h3><p><span>A total of 35 healthy participants will be included and receive acupuncture stimulation with RMHS and RMCS in a random order. The psychology, cognition, and body constitution of participants will be measured by the Self-rating Anxiety Scale (SAS), the Self-rating Depression Scale (SDS), the mindful attention awareness scale (MAAS), the Constitution in Chinese Medicine Questionnaire (CCMQ), and the needle sensation will be evaluated after each acupuncture stimulation immediately. 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Real-time cerebral response of two classic acupuncture manipulations: Protocol for a randomized crossover fNIRS trial 两种不同古典针刺手法的实时中枢整合特征研究:一项基于近红外光谱成像技术的随机交叉试验研究方案
Background
Reinforcing-reducing manipulations are a crucial part of acupuncture therapy. The reinforcing manipulation with heat sensation (RMHS) and the reducing manipulation by inducing cool sensation (RMCS) are two representative methods of reinforcing-reducing manipulations. This trial aims to investigate the characteristic of cerebral responses to these two typical acupuncture manipulations.
Methods
A total of 35 healthy participants will be included and receive acupuncture stimulation with RMHS and RMCS in a random order. The psychology, cognition, and body constitution of participants will be measured by the Self-rating Anxiety Scale (SAS), the Self-rating Depression Scale (SDS), the mindful attention awareness scale (MAAS), the Constitution in Chinese Medicine Questionnaire (CCMQ), and the needle sensation will be evaluated after each acupuncture stimulation immediately. The cerebral activity changes elicited by RMHS and RMCS will be detected by functional near-infrared spectroscopy (fNIRS) and analyzed with the general linear model-based activation and the channel-to-channel functional connectivity.
Discussion
This trial will investigate the cerebral response induced by RMHS and RMCS by real-time fNIRS, so as to map the characteristics of the central responses’ patterns to these two manipulations and preliminarily explore the mechanism of traditional acupuncture manipulations.
Trial registration
Chinese Clinical Trials. gov Registry (ChiCTR2100051886).
期刊介绍：
The focus of the journal includes, but is not confined to, clinical research, summaries of clinical experiences, experimental research and clinical reports on needling techniques, moxibustion techniques, acupuncture analgesia and acupuncture anesthesia.
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