{"title":"水凝胶伤口敷料的研究进展与挑战","authors":"Wenda Wang , Sarute Ummartyotin , Ravin Narain","doi":"10.1016/j.cobme.2022.100443","DOIUrl":null,"url":null,"abstract":"<div><p>Hydrogels, due to their hydrophilic nature, tunable chemical, mechanical and biological properties, have shown great promises for wound dressing application. Nevertheless, conventional hydrogels can only passively participate in the wound healing process by maintaining the moisture around wound, which limits the wound healing efficacy. Recent developments of hydrogel wound dressings have focused on the mechanically active adhesive hydrogels and self-adapting hydrogels, which are able to actively accelerate the wound healing process. In this review, we first review the design strategies and function mechanisms of both types of hydrogel dressings, followed by the discussion on the application of those hydrogel dressings for the treatment of different type of wounds. Finally, we present the future trends and research opportunities for the development of next generation “smart” hydrogel materials for wound healing application.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":"26 ","pages":"Article 100443"},"PeriodicalIF":4.7000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"9","resultStr":"{\"title\":\"Advances and challenges on hydrogels for wound dressing\",\"authors\":\"Wenda Wang , Sarute Ummartyotin , Ravin Narain\",\"doi\":\"10.1016/j.cobme.2022.100443\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Hydrogels, due to their hydrophilic nature, tunable chemical, mechanical and biological properties, have shown great promises for wound dressing application. Nevertheless, conventional hydrogels can only passively participate in the wound healing process by maintaining the moisture around wound, which limits the wound healing efficacy. Recent developments of hydrogel wound dressings have focused on the mechanically active adhesive hydrogels and self-adapting hydrogels, which are able to actively accelerate the wound healing process. In this review, we first review the design strategies and function mechanisms of both types of hydrogel dressings, followed by the discussion on the application of those hydrogel dressings for the treatment of different type of wounds. Finally, we present the future trends and research opportunities for the development of next generation “smart” hydrogel materials for wound healing application.</p></div>\",\"PeriodicalId\":36748,\"journal\":{\"name\":\"Current Opinion in Biomedical Engineering\",\"volume\":\"26 \",\"pages\":\"Article 100443\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2023-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Biomedical Engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468451122000769\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Biomedical Engineering","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468451122000769","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Advances and challenges on hydrogels for wound dressing
Hydrogels, due to their hydrophilic nature, tunable chemical, mechanical and biological properties, have shown great promises for wound dressing application. Nevertheless, conventional hydrogels can only passively participate in the wound healing process by maintaining the moisture around wound, which limits the wound healing efficacy. Recent developments of hydrogel wound dressings have focused on the mechanically active adhesive hydrogels and self-adapting hydrogels, which are able to actively accelerate the wound healing process. In this review, we first review the design strategies and function mechanisms of both types of hydrogel dressings, followed by the discussion on the application of those hydrogel dressings for the treatment of different type of wounds. Finally, we present the future trends and research opportunities for the development of next generation “smart” hydrogel materials for wound healing application.