盐酸硫胺素作为一种可回收的有机催化剂，用于胺的高效化学选择性n -叔丁基羰基化

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2021-12-17 DOI:10.1080/00397911.2021.1994998

Ajit P. Ingale , Dnyaneshwar N. Garad , Dattatraya Ukale , Nitin M. Thorat , Sandeep V. Shinde

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引用次数: 2

摘要

本文描述了在无溶剂条件下，以盐酸硫胺素促进胺的n -叔丁基氧羰基化的高效、环保方法。该方法适用于多种脂肪族、芳基、杂芳基胺的N-Boc保护。手性胺和氨基醇的化学选择性保护不发生外消旋，产率高。盐酸硫胺稳定、经济、易操作、环保。

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Thiamine hydrochloride as a recyclable organocatalyst for the efficient and chemoselective N-tert-butyloxycarbonylation of amines

Abstract Thiamin hydrochloride promoted highly efficient and ecofriendly approach has been described for the chemoselective N-tert-butyloxycarbonylation of amines under solvent-free conditions at ambient temperature. The demonstrated approach has been applicable for the N-Boc protection of variety of aliphatic, aryl, heteroaryl amines. The chemoselective protection of amino group occurs in chiral amines and amino alcohol without racemization in high yield. Thiamin hydrochloride is stable, economical, easy to handle and environmentally friendly. Graphical Abstract

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.