首次原位合成1,3-二恶烷-5- 1衍生物及其在Claisen-Schmidt反应中的直接应用

IF 1.3 3区化学 Q3 CHEMISTRY, ORGANIC

Heterocyclic Communications Pub Date : 2019-01-01 DOI:10.1515/hc-2019-0013

M. Javad Poursharifi, M. M. Mojtahedi, M. Saeed Abaee, M. Hashemi

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引用次数: 2

摘要

摘要建立了一种原位生成1,3-二恶烷-5- 1衍生物2的方法。这些化合物是获得碳水化合物结构的简单前体，以前必须通过使用过量试剂的逐步程序生产。本文以三烷氧基烷烃为原料，以二羟基丙酮二聚体1为催化剂，在乙酸的催化下合成了三种不同的2衍生物。在同一锅中，2的衍生物与芳香醛和30mol %的吡咯烷反应，在短时间内得到了相应的双查尔酮3的高产率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The first in situ synthesis of 1,3-dioxan-5-one derivatives and their direct use in Claisen-Schmidt reactions

Abstract A method is developed for in situ generation of 1,3-dioxan-5-one derivatives 2. These compounds are simple precursors for accessing carbohydrate structures and previously had to be produced via stepwise procedures using excessive amounts of reagents. In the present work, three different derivatives of 2 were synthesized via the reaction of trialkoxyalkanes with dihydroxyacetone dimer 1 in the presence of acetic acid as the catalyst. In the same pot, derivatives of 2 were reacted with aromatic aldehydes and 30 mol% of pyrrolidine to obtain high yields of the respective bischalcones 3 within short time periods.

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来源期刊

Heterocyclic Communications 化学-有机化学

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

1.4 months

期刊介绍： Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.