新型5,6,7,8-四氢苯并[b]吡喃衍生物的合成及其抗癌活性

IF 1.2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Acta Chimica Slovenica Pub Date : 2023-06-20 DOI:10.17344/acsi.2022.7893

A. Abdallah, R. Mohareb, M. H. Helal, Mariam M. Abd Elkader

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引用次数: 0

摘要

设计并制备了许多具有潜在抗癌活性的新型吡喃环化体系。吡喃系对各种化学试剂表现出较高的反应活性。从所制备的化合物中筛选出24个产物，并在(mM)中作为良好的抗癌因子进行了测试。结果表明，化合物3b、6b和8与标准对照福替尼相比，对A-549(肺癌)、HC-29(结直肠癌)和MKN-45(胃癌)三种癌细胞系具有广泛的抑制作用。

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Novel 5,6,7,8-tetrahydrobenzo[b]pyran Derivatives: Synthesis and Anticancer Activity

Many new cyclized pyran systems with a potential anti-cancer activity were designed and prepared. Pyran systems showed high reactivity to various chemical reagents. 24 products of the prepared compounds were chosen and tested in (mM) as respectable anticancer factors. The findings revealed that compounds 3b, 6b, and 8 were the widely effective compounds against the three cancer cell lines including A-549 (lung carcinoma), HC-29 (colorectal adenocarcinoma), and MKN-45 (gastric cancer) compared to the standard reference control foretinib.

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来源期刊

Acta Chimica Slovenica 化学-化学综合

CiteScore

2.50

自引率

25.00%

发文量

审稿时长

1.0 months

期刊介绍： Is an international, peer-reviewed and Open Access journal. It provides a forum for the publication of original scientific research in all fields of chemistry and closely related areas. Reviews, feature, scientific and technical articles, and short communications are welcome.