Zhiwei Li , Xueer Wang , Wei Wang , Ran An , Yaxin Wang , Qingchang Ren , Jingjing Xuan
{"title":"三丁酸甘油酯对断奶小尾寒羔羊生长性能、胃肠道发育、瘤胃细菌和挥发性脂肪酸形成的影响","authors":"Zhiwei Li , Xueer Wang , Wei Wang , Ran An , Yaxin Wang , Qingchang Ren , Jingjing Xuan","doi":"10.1016/j.aninu.2023.08.006","DOIUrl":null,"url":null,"abstract":"<div><p>This study aimed to determine the effects of tributyrin on growth performance, gastrointestinal tract development, ruminal bacteria and volatile fatty acid (VFA) formation. Thirty healthy weaned Small-Tailed Han female lambs at 3 months old with BW 27.5 ± 4.1 kg (mean ± SD) were randomly assigned to five groups of six lambs each, and each group received tributyrin at 0, 0.5, 1.0, 2.0 and 4.0 g/kg in feed. Weights were measured before the start and end of the study. After 15 d adaptation, DMI, feed, faeces and urine were recorded every week. Lambs were sacrificed at d 75. Compared to lambs fed no tributyrin, lambs fed 4.0 g/kg tributyrin had higher average daily BW gain (<em>P</em> = 0.04) and DMI (<em>P</em> < 0.01). Tributyrin reduced nitrogen (<em>P</em> < 0.01), Ca (<em>P</em> < 0.01) and P (<em>P</em> < 0.01) losses derived from faeces and urine. The mostly important, tributyrin increased dorsal sac thickness (<em>P</em> < 0.01), papillae length (<em>P</em> = 0.04) and width (<em>P</em> < 0.01), ventral sac papillae length (<em>P</em> < 0.01) and width (<em>P</em> < 0.01), caudodorsal blind sac thickness (<em>P</em> = 0.02), papillae length (<em>P</em> < 0.01) and width (<em>P</em> < 0.01). Furthermore, tributyrin increased thicknesses of both the duodenum (<em>P</em> < 0.01) and ileum (<em>P</em> = 0.01), and villus heights of the duodenum (<em>P</em> = 0.01), ileum (<em>P</em> < 0.01), jejunum (<em>P</em> < 0.01) and caecum (<em>P</em> = 0.02), but tributyrin decreased duodenal (<em>P</em> < 0.01) and caecal crypt depths (<em>P</em> < 0.01). Tributyrin reduced rumen pH (<em>P</em> < 0.01) while promoting total VFA concentration (<em>P</em> < 0.01). Tributyrin improved the structure of rumen bacteria by enhancing <em>Clostridium</em> (<em>P</em> = 0.04), <em>Butyrivibrio</em> (<em>P</em> < 0.01), <em>Streptococcus</em> (<em>P</em> = 0.04), <em>Prevotella</em> (<em>P</em> = 0.04), <em>Ruminobacter</em> (<em>P</em> = 0.02) and <em>Fibrobacter</em> (<em>P</em> = 0.03). In conclusion, tributyrin could stimulate gastrointestinal tract development by enhancing colonization of rumen VFA-producing bacteria, and dietary supplementation of tributyrin at 4.0 g/kg of DM was recommended for the weaned lambs.</p></div>","PeriodicalId":62604,"journal":{"name":"Animal Nutrition","volume":"15 ","pages":"Pages 187-196"},"PeriodicalIF":6.3000,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405654523001038/pdfft?md5=b875cd903910bedb922e67cba8cd832e&pid=1-s2.0-S2405654523001038-main.pdf","citationCount":"1","resultStr":"{\"title\":\"Benefits of tributyrin on growth performance, gastrointestinal tract development, ruminal bacteria and volatile fatty acid formation of weaned Small-Tailed Han lambs\",\"authors\":\"Zhiwei Li , Xueer Wang , Wei Wang , Ran An , Yaxin Wang , Qingchang Ren , Jingjing Xuan\",\"doi\":\"10.1016/j.aninu.2023.08.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>This study aimed to determine the effects of tributyrin on growth performance, gastrointestinal tract development, ruminal bacteria and volatile fatty acid (VFA) formation. Thirty healthy weaned Small-Tailed Han female lambs at 3 months old with BW 27.5 ± 4.1 kg (mean ± SD) were randomly assigned to five groups of six lambs each, and each group received tributyrin at 0, 0.5, 1.0, 2.0 and 4.0 g/kg in feed. Weights were measured before the start and end of the study. After 15 d adaptation, DMI, feed, faeces and urine were recorded every week. Lambs were sacrificed at d 75. Compared to lambs fed no tributyrin, lambs fed 4.0 g/kg tributyrin had higher average daily BW gain (<em>P</em> = 0.04) and DMI (<em>P</em> < 0.01). Tributyrin reduced nitrogen (<em>P</em> < 0.01), Ca (<em>P</em> < 0.01) and P (<em>P</em> < 0.01) losses derived from faeces and urine. The mostly important, tributyrin increased dorsal sac thickness (<em>P</em> < 0.01), papillae length (<em>P</em> = 0.04) and width (<em>P</em> < 0.01), ventral sac papillae length (<em>P</em> < 0.01) and width (<em>P</em> < 0.01), caudodorsal blind sac thickness (<em>P</em> = 0.02), papillae length (<em>P</em> < 0.01) and width (<em>P</em> < 0.01). Furthermore, tributyrin increased thicknesses of both the duodenum (<em>P</em> < 0.01) and ileum (<em>P</em> = 0.01), and villus heights of the duodenum (<em>P</em> = 0.01), ileum (<em>P</em> < 0.01), jejunum (<em>P</em> < 0.01) and caecum (<em>P</em> = 0.02), but tributyrin decreased duodenal (<em>P</em> < 0.01) and caecal crypt depths (<em>P</em> < 0.01). Tributyrin reduced rumen pH (<em>P</em> < 0.01) while promoting total VFA concentration (<em>P</em> < 0.01). Tributyrin improved the structure of rumen bacteria by enhancing <em>Clostridium</em> (<em>P</em> = 0.04), <em>Butyrivibrio</em> (<em>P</em> < 0.01), <em>Streptococcus</em> (<em>P</em> = 0.04), <em>Prevotella</em> (<em>P</em> = 0.04), <em>Ruminobacter</em> (<em>P</em> = 0.02) and <em>Fibrobacter</em> (<em>P</em> = 0.03). In conclusion, tributyrin could stimulate gastrointestinal tract development by enhancing colonization of rumen VFA-producing bacteria, and dietary supplementation of tributyrin at 4.0 g/kg of DM was recommended for the weaned lambs.</p></div>\",\"PeriodicalId\":62604,\"journal\":{\"name\":\"Animal Nutrition\",\"volume\":\"15 \",\"pages\":\"Pages 187-196\"},\"PeriodicalIF\":6.3000,\"publicationDate\":\"2023-08-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2405654523001038/pdfft?md5=b875cd903910bedb922e67cba8cd832e&pid=1-s2.0-S2405654523001038-main.pdf\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Animal Nutrition\",\"FirstCategoryId\":\"1091\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405654523001038\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Animal Nutrition","FirstCategoryId":"1091","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405654523001038","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Benefits of tributyrin on growth performance, gastrointestinal tract development, ruminal bacteria and volatile fatty acid formation of weaned Small-Tailed Han lambs
This study aimed to determine the effects of tributyrin on growth performance, gastrointestinal tract development, ruminal bacteria and volatile fatty acid (VFA) formation. Thirty healthy weaned Small-Tailed Han female lambs at 3 months old with BW 27.5 ± 4.1 kg (mean ± SD) were randomly assigned to five groups of six lambs each, and each group received tributyrin at 0, 0.5, 1.0, 2.0 and 4.0 g/kg in feed. Weights were measured before the start and end of the study. After 15 d adaptation, DMI, feed, faeces and urine were recorded every week. Lambs were sacrificed at d 75. Compared to lambs fed no tributyrin, lambs fed 4.0 g/kg tributyrin had higher average daily BW gain (P = 0.04) and DMI (P < 0.01). Tributyrin reduced nitrogen (P < 0.01), Ca (P < 0.01) and P (P < 0.01) losses derived from faeces and urine. The mostly important, tributyrin increased dorsal sac thickness (P < 0.01), papillae length (P = 0.04) and width (P < 0.01), ventral sac papillae length (P < 0.01) and width (P < 0.01), caudodorsal blind sac thickness (P = 0.02), papillae length (P < 0.01) and width (P < 0.01). Furthermore, tributyrin increased thicknesses of both the duodenum (P < 0.01) and ileum (P = 0.01), and villus heights of the duodenum (P = 0.01), ileum (P < 0.01), jejunum (P < 0.01) and caecum (P = 0.02), but tributyrin decreased duodenal (P < 0.01) and caecal crypt depths (P < 0.01). Tributyrin reduced rumen pH (P < 0.01) while promoting total VFA concentration (P < 0.01). Tributyrin improved the structure of rumen bacteria by enhancing Clostridium (P = 0.04), Butyrivibrio (P < 0.01), Streptococcus (P = 0.04), Prevotella (P = 0.04), Ruminobacter (P = 0.02) and Fibrobacter (P = 0.03). In conclusion, tributyrin could stimulate gastrointestinal tract development by enhancing colonization of rumen VFA-producing bacteria, and dietary supplementation of tributyrin at 4.0 g/kg of DM was recommended for the weaned lambs.
期刊介绍：
Animal Nutrition encompasses the full gamut of animal nutritional sciences and reviews including, but not limited to, fundamental aspects of animal nutrition such as nutritional requirements, metabolic studies, body composition, energetics, immunology, neuroscience, microbiology, genetics and molecular and cell biology related to primarily to the nutrition of farm animals and aquatic species. More applied aspects of animal nutrition, such as the evaluation of novel ingredients, feed additives and feed safety will also be considered but it is expected that such studies will have a strong nutritional focus. Animal Nutrition is indexed in SCIE, PubMed Central, Scopus, DOAJ, etc.
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