P.35在内皮药理学阻断下，TASK-1通道在大鼠冠状动脉间隔中发挥抗收缩作用

IF 1.6 4区医学 Q4 PERIPHERAL VASCULAR DISEASE

Artery Research Pub Date : 2020-12-01 DOI:10.2991/artres.k.201209.048

B. S. V. Lazarenko, A. Shvetsova, D. Gaynullina, R. Schubert

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引用次数: 1

摘要

目的/背景/目的：TASK-1（TWIK相关酸敏感钾）通道在肺动脉平滑肌细胞中传导背景K+电流，抑制血管收缩。然而，TASK-1通道在系统动脉中的血管舒缩作用及其通过内皮的调节尚不清楚。因此，我们研究了TASK-1通道在存在或不存在脑和心脏（系统循环的重要区域）内皮舒张影响的情况下对动脉收缩调节的影响。

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P.35 TASK-1 Channels Play an Anticontractile Role in Rat Septal Coronary Artery Under Pharmacological Blockade of Endothelium

Purpose/Background/Objectives: TASK-1 (TWIK-related acid-sensitive potassium) channels conduct background K+ currents in smooth muscle cells of pulmonary arteries suppressing vasocontraction. However, the vasomotor role of TASK-1 channels in systemic arteries as well as their regulation by the endothelium are poorly understood. Therefore, we investigated the impact of TASK-1 channels on the regulation of arterial contraction in the presence or absence of the relaxing influence of the endothelium in the brain and the heart, important regions of the systemic circulation.

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来源期刊

Artery Research Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.70

自引率

16.70%

发文量

审稿时长

13 weeks

期刊介绍： Artery Research is the official journal of the Association for Research into Arterial Structure and Physiology (ARTERY) which promotes the advancement of knowledge and dissemination of information concerning the pathophysiology, epidemiology, detection, investigation and treatment of arterial structure and function. The journal publishes original research articles, review articles, perspectives, case-studies, letters to the Editor, short communications and images. All submitted material is subject to a strict peer-review process.