全球稳定蛋白转录动力学的振荡模型

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
H. Díaz-Marín, O. Osuna, G. Villavicencio-Pulido
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引用次数: 0

摘要

振荡出现在生物组织的各个层次。振荡现象并不总是具有简单的周期性。在这项工作中,我们分析了一个基因转录网络,在这个网络中,我们假设一个几乎周期性的输入来调节基因。我们使用几乎周期性的输入[公式:见文本],因为周期性的输入是非常严格的。我们证明了所提出的概周期模型具有唯一的概周期吸引子。数值模拟结果表明,当上游系统与下游系统相互连接时,几乎周期性输入对系统的回溯性影响很大。通过对模型解的比较,我们可以得出结论,当结合到启动子上的蛋白质量用周期函数或几乎周期函数建模时,用[公式:见文]表示,蛋白质浓度[公式:见文]的量可以被低估或高估,这取决于[公式:见文]是用周期函数还是几乎周期函数建模。这些估计误差可能导致追溯性量化的误差,进而可能改变上游系统和下游系统之间的协调。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
AN OSCILLATORY MODEL FOR GLOBALLY STABLE PROTEIN TRANSCRIPTION DYNAMICS
Oscillations appear in all levels of biological organization. Oscillatory phenomena do not always possess a simple periodic nature. In this work, we analyze a gene transcriptional network in which we assume an almost periodic input that regulates gene. We use an almost periodic input [Formula: see text] since a periodic one is very restrictive. We show that the almost periodic model proposed has a unique almost periodic attractor. Numerical simulations show that the retroactivity is highly affected when an almost periodic input is used in an upstream system that is interconnected to a downstream system. By comparison of the solutions of the model, we can conclude that when the amount of protein bound to the promoter is modeled by either a periodic function or an almost periodic one, which is denoted by [Formula: see text], the amount of protein concentration [Formula: see text] can be underestimated or overestimated depending on if [Formula: see text] is modeling by a periodic or an almost periodic function. These estimation errors can lead to an error in the quantification of retroactivity which in turn can alter the coordination between an upstream system and a downstream one.
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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