The model of electrified cell clusters in biological tissues basing on the resting potential difference

The resting potential is the potential difference that exists between the inner and outer sides of the cell membrane when the cell is not stimulated. The resting membrane potential is a key regulator of phenomena such as cell proliferation, morphogenesis, migration and differentiation. In this paper, we proposed a model of electrified cell clusters that considers the resting potential of cell clusters in the resting state. By measuring the potential difference between the inner and outer sides of biological tissues, it is verified that the cell cluster has a negative potential difference when taking the outer potential as the reference. In the absence of external conductors, the tissue is electrically neutral; while in the presence of external conductors, the positive net charges escape freely under repulsive forces and the biological tissues form a negative electrical equilibrium system. The model proposed in this study explored the potential situation above the cellular level in the resting state, providing a new perspective for the research on resting potential.