基于全氟丙烷-2-基的新型喹啉衍生物的合成及抑菌活性研究

IF 1.3 3区化学 Q3 CHEMISTRY, ORGANIC

Heterocyclic Communications Pub Date : 2019-01-01 DOI:10.1515/hc-2019-0002

Zai Zhang, Minhua Liu, Weidong Liu, J. Xiang, Jianming Li, Zhong Li, Xingping Liu, Mingzhi Huang, Aiping Liu, Xingliang Zheng

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引用次数: 6

摘要

摘要以丁咯喹为先导化合物，设计合成了一系列新的全氟丙烷-2-基喹啉衍生物。通过波谱数据1HNMR、MS和元素分析证实了所有新合成的化合物的结构。生物测定结果表明，这些化合物具有较强的杀菌活性。特别是化合物8c表现出优异的活性，EC50值为1.48mg/L，优于市售杀菌剂丁咯喹。并对这些新化合物的构效关系进行了讨论。

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Synthesis and fungicidal activities of perfluoropropan-2-yl-based novel quinoline derivatives

Abstract A series of novel perfluoropropan-2-yl-based quinoline derivatives was designed and synthesized utilizing tebufloquin as the lead compound. The structures of all the newly synthesized compounds were confirmed by spectroscopic data 1HNMR, MS and elemental analysis. The results of bioassay indicated that these compounds exhibited potent fungicidal activities against Erysiphe graminis. Especially, compound 8c displayed excellent activity with EC50 value at 1.48 mg / L, which was better than that of the commercialized fungicide --- tebufloquin. The structure-activity relationship for these new compounds was also discussed.

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来源期刊

Heterocyclic Communications 化学-有机化学

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

1.4 months

期刊介绍： Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.