A. K. Pathan, Pravinkumar Patil, A. Shinde, S. Zangade
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Eco-friendly and Green Procedure for Iodination of Reactive Aromatics Using PEG 400-I2/HIO3 Combination
Iodination of organic substrate is an important reaction for synthesis of pharmacological active
molecules.
In view of these concerns, we reported the convenient procedure for synthesis of iodo compounds using iodine
and iodic acid in PEG-400.We have reported the eco-friendly procedure for preparation of aromatic iodo compounds using
iodine and iodic acid in green reaction media as polyethylene glycol (PEG-400).
The iodination of some aromatic compounds such as benzaldehydes, acetophenones, phenols, amines and
heterocyclic compounds carried out using iodine, iodic acid and PEG-400. The synthesized substituted aromatic iodo
compounds were confirmed based on spectral characterization and mixed melting points.
The method comprises several advantages such as simple reaction procedure, easy isolation, quantitative
yields, and purity of iodo products.
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