干扰素对人类病毒感染的治疗作用

Q4 Biochemistry, Genetics and Molecular Biology
Hebert Jair Barrales-Cureño, C. Reyes-Reyes, Maximino Díaz-Bautista, A. D. Jesús, Salvador Chávez-Salinas, L. G. López-Valdez
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引用次数: 0

摘要

干扰素(IFN)是免疫活性细胞对各种刺激产生的一种细胞因子。五种类型的ifn被确定:α, β, γ, tau和ω - 1。特别是,干扰素通过抗病毒机制直接抑制病毒复制,因为它们通过放大对病毒蛋白的免疫反应间接抑制病毒复制。同样,它们也是临床肿瘤学的基本要素。它们被用于治疗慢性髓细胞和毛细胞白血病、多发性骨髓瘤、非霍奇金淋巴瘤、黑色素瘤、肾癌和卡波西肉瘤,以及乳头状瘤。它们还用于病毒性疾病,如乙型肝炎和丙型肝炎、急性呼吸系统综合症和艾滋病毒(实验中为后者),以及神经退行性疾病,包括多发性硬化症或肌萎缩性侧索硬化症。干扰素与其他治疗方法的结合有助于增强其抗病毒和抗肿瘤活性。这项工作的目的是提出一个最新的参考干扰素在医学领域的使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Therapeutic effects of interferons in human viral infections
The interferon (IFN) is a cytokine produced by immunocompetent cells in response to various stimuli. Five types of IFNs are identified: alpha, beta, gamma, tau and omega 1. In particular, interferons inhibit viral replication directly by antiviral mechanisms, as they do so indirectly by amplifying immune responses to viral proteins. Likewise, they are also essential elements in clinical oncology. They are used in the treatment of chronic myelocytic and hairy cell leukemia, multiple myeloma, non-Hodgkin's lymphoma, melanoma, renal carcinoma, and Kaposi's sarcoma, as well as in the papilloma. They are also used in diseases of viral origin such as hepatitis B and C, acute respiratory syndrome, and HIV (experimentally in the latter), as well as in neurodegenerative diseases, including multiple sclerosis or amyotrophic lateral sclerosis. The combination of interferons with other therapies is contributing to enhance its antiviral and antitumor activity. This work aims to present an updated reference on the use of interferons in the medical field.
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来源期刊
Mexican Journal of Biotechnology
Mexican Journal of Biotechnology Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
1.30
自引率
0.00%
发文量
12
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