SIR和SEIR模型远高于流行阈值的渐近解

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
G. Kozyreff
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引用次数: 2

摘要

在大基本繁殖数${\mathsfR_0}$的渐近极限下,构造了Kermack和McKendrick SIR流行病模型解的一个简单而明确的表达式。当${\mathsf R_0}\geq3$时,所提出的公式已经产生了良好的定性一致性,并且当假定${\ mathsf R_0}$的值较大时,该公式迅速变得定量准确。该推导基于匹配渐近展开法,该方法利用了疫情的指数增长阶段和最终衰退发生在不同的时间尺度上的事实。从新导出的解中,给出了流行病曲线第一拐点与感染高峰分离时间的分析估计。最后,我们在SEIR模型上使用了相同的方法,发现将“暴露”人群纳入模型可以显著改变疫情的时间尺度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Asymptotic solutions of the SIR and SEIR models well above the epidemic threshold
A simple and explicit expression of the solution of the SIR epidemiological model of Kermack and McKendrick is constructed in the asymptotic limit of large basic reproduction numbers ${\mathsf R_0}$. The proposed formula yields good qualitative agreement already when ${\mathsf R_0}\geq 3$ and rapidly becomes quantitatively accurate as larger values of ${\mathsf R_0}$ are assumed. The derivation is based on the method of matched asymptotic expansions, which exploits the fact that the exponential growing phase and the eventual recession of the outbreak occur on distinct time scales. From the newly derived solution, an analytical estimate of the time separating the first inflexion point of the epidemic curve from the peak of infections is given. Finally, we use the same method on the SEIR model and find that the inclusion of the ‘exposed’ population in the model can dramatically alter the time scales of the outbreak.
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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