氨基氰吡唑的反应性研究及部分产物的线粒体还原功能评价

IF 1.3 3区化学 Q3 CHEMISTRY, ORGANIC

Heterocyclic Communications Pub Date : 2022-01-01 DOI:10.1515/hc-2022-0001

Soumaya Bellili, N. J. Coltman, N. Hodges, F. Allouche

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引用次数: 1

摘要

摘要研究了以氨基氰吡唑1为前体加速合成功能化三氟甲基吡唑嘧啶3和N-(5-氰基-3-甲基-1-苯基- 1h -吡唑-4-基)苯酰胺4的一般高通量合成工艺。发现氯磺酰异氰酸酯(CSI)与氨基吡唑[3,4-d]嘧啶2的作用产生了三唑嘧啶5。量化线粒体还原功能的MTT试验表明，在所测试的两种细胞系(PE/CA-PJ41和HePG2细胞)中，苯甲酰胺化合物4对PE/CA-PJ41细胞具有中等毒性，比HePG2细胞更敏感。

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Study of the reactivity of aminocyanopyrazoles and evaluation of the mitochondrial reductive function of some products

Abstract This research investigated the general high-throughput synthetic protocol for the accelerated synthesis of functionalized trifluoromethylpyrazolopyrimidines 3 and N-(5-cyano-3-methyl-1-phenyl-1H-pyrazol-4-yl) benzamide 4 from aminocyanopyrazole 1 precursors. The action of chlorosulfonyl isocyanate (CSI) with aminopyrazolo[3,4-d]pyrimidines 2 was found to produce triazolopyrimidinones 5 . The MTT test that quantifies mitochondrial reductive function demonstrated that in both cell lines tested (PE/CA-PJ41 and HePG2 cells), the benzamide compounds 4 are moderately toxic with PE/CA-PJ41 cells and more sensitive than HePG2 cells.

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来源期刊

Heterocyclic Communications 化学-有机化学

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

1.4 months

期刊介绍： Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.