在尼日利亚高原州乔斯的活着的信念基金会接受产后护理的儿童中的血红蛋白基因型变异和恶性疟原虫疟疾

H. Njila, J. Idoko, A. Ombugadu, H. Zakari
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引用次数: 1

摘要

越来越多的数据显示血红蛋白基因型与恶性疟原虫疟疾之间存在联系。为了确定在高原州Faith Alive Foundation Jos接受产后护理的儿童中血红蛋白基因型变异的患病率及其与恶性疟原虫疟疾的关系,我们研究了这些变异的分布。从每个样品中,制作厚血膜和薄血膜,并使用电泳确定血红蛋白基因型。172份样本中,131份(76.16%)感染恶性疟原虫,41份(23.84%)未感染。不同血红蛋白基因型间恶性疟原虫分布差异无统计学意义(p < 0.05)。恶性疟原虫在AA区最多,92例(70%),SS区最少,12例(9%)。恶性疟原虫患病率与年龄的关系无统计学差异(p < 0.05)。≥12月龄组恶性疟原虫感染率高于0 ~ 11月龄组。恶性疟原虫患病率在性别上差异无统计学意义(p < 0.05)。结果表明,恶性疟原虫感染的男性多于女性。不同月份间恶性疟原虫患病率差异无统计学意义(p < 0.05)。9月是恶性疟原虫流行率最高的月份,其次是10月和8月。因此,建议加强针对母亲和保健工作者的公共卫生教育运动,以提高认识,从而减少人类媒介接触,特别是在儿童中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hemoglobin genotype variants and Plasmodium Falciparum malaria in children receiving postpartum care at Faith Alive Foundation Jos, Plateau State, Nigeria
More and more data are showing a link between hemoglobin genotypes and Plasmodium falciparum malaria. In order to establish the prevalence of hemoglobin genotype variants and their association with P. falciparum malaria in children receiving postpartum care at Faith Alive Foundation Jos, Plateau State, we study the distribution of these variants. From each sample, thick and thin blood films were created, and hemoglobin genotypes were determined using electrophoresis. Out of 172 samples examined, 131 (76.16%) were infected with P. falciparum malaria while 41 (23.84%) were not infected. There was no significant difference (p > 0.05) in the distribution of P. falciparum malaria in relation to hemoglobin genotypes. P. falciparum malaria was highest in AA with 92 (70%) and SS was the least with 12 (9%). There was no significant difference (p > 0.05) in th+++e prevalence of P. falciparum malaria in relation to age. P. falciparum malaria infection was highest in the age group ≥ 12 months than age group 0 - 11 months. There was no significant difference (p > 0.05) in the prevalence of P. falciparum malaria in relation to sex. The result depicted that P. falciparum malaria infects more males than females. There was also no significant difference (p > 0.05) in the prevalence of P. falciparum malaria in relation to months. The month of September had the highest prevalence of P. falciparum malaria followed by October and August respectively. It is, therefore, recommended that public health education campaigns for mothers and healthcare givers be intensified to create awareness that will lead to the reduction of human-vector contact, especially in children.
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