肾移植结果:单中心经验

Q4 Medicine
Jamilya Saparbay , Mels Assykbayev , Saitkarim Abdugafarov , Gulnur Zhakhina , Saniya Abdrakhmanova , Aida Turganbekova , Zhuldyz Zhanzakova , Kulkayeva Gulnara
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引用次数: 0

摘要

简介:慢性肾脏疾病(CKD)是医疗保健系统的主要负担之一,不仅在哈萨克斯坦。CKD患者的数量每年都在增加。在肾脏替代方法中,肾移植(KTx)是最好的治疗选择。KTx从2010年开始在哈萨克斯坦演出。各种因素可以改善或恶化KTx后的结果。我们分析了影响移植物存活的因素。我们进行这项研究的目的是为了发现显著影响KTx预后的因素,最好是来自活体供体。方法:收集国家肿瘤研究中心档案中253例肾受体的临床资料并进行回顾性分析。结果:发现KTx前免疫状态影响预后。HLA I类抗体的存在与移植物损失显著相关(p=0.046)。HLAⅱ类抗体与移植物损失的共存无统计学意义(p=0.324)。术后急性排斥反应与移植物丢失高度相关(p<0.001)。在该队列中,18例(7%)发生急性排斥反应,其中13例(72%)为女性(p<0.001)。移植物存活与受者性别有统计学意义,p=0.002。女性移植的5年生存率为80.2%,而男性为95.3%。结论:受者性别、免疫状态和移植后急性排斥反应是移植后1年肾功能恶化的预测因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Kidney transplantation outcomes: Single center experience

Introduction: Chronic kidney disease (CKD) is one of the main burden for healthcare system not only in Kazakhstan. The number of patients with CKD increases annually. Among renal replacement approaches, kidney transplantation (KTx) is the best therapeutic option. KTx is performed in Kazakhstan since 2010. Various factor can either improve or deteriorate outcome after KTx. Here we analyzed factors, influencing graft survival. We have performed this study in order to detect the factors, that significantly affects the KTx outcomes, preferably from living donor

Methods: Clinical data of the 253 kidney recipients were collected from archives of National Research oncology center and retrospectively analyzed.

Results: Immunological status before KTx was found to affect outcome. The presence of HLA class I antibodies was significantly related to graft loss (p=0.046).Coexistence of HLA class II antibodies and the graft loss was not significant (p=0.324). Acute postoperative rejection was highly correlated with graft loss (p<0.001). Of the cohort, 18 (7%) had acute rejection, and 13 (72%) of them were women (p<0.001). The graft survival was statistically significantly related to the gender of the recipient with p=0.002. The 5-year survival of a graft in females was 80.2%, while for males it was 95.3%. In addition, post-operational complications remarkably influenced the graft loss with p=0.005

Conclusion: Recipients' gender, immunological status, and acute graft rejection episodes after transplantation were predictors of a worse kidney function 1 year after transplantation.

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来源期刊
Transplantation Reports
Transplantation Reports Medicine-Transplantation
CiteScore
0.60
自引率
0.00%
发文量
24
审稿时长
101 days
期刊介绍: To provide to national and regional audiences experiences unique to them or confirming of broader concepts originating in large controlled trials. All aspects of organ, tissue and cell transplantation clinically and experimentally. Transplantation Reports will provide in-depth representation of emerging preclinical, impactful and clinical experiences. -Original basic or clinical science articles that represent initial limited experiences as preliminary reports. -Clinical trials of therapies previously well documented in large trials but now tested in limited, special, ethnic or clinically unique patient populations. -Case studies that confirm prior reports but have occurred in patients displaying unique clinical characteristics such as ethnicities or rarely associated co-morbidities. Transplantation Reports offers these benefits: -Fast and fair peer review -Rapid, article-based publication -Unrivalled visibility and exposure for your research -Immediate, free and permanent access to your paper on Science Direct -Immediately citable using the article DOI
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