孤立性促肾上腺皮质激素缺乏并不总是永久性的

N. A. Jurayyan
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引用次数: 0

摘要

肾上腺皮质激素(ACTH)缺乏是垂体功能减退症最危及生命的特征。孤立的肾上腺皮质激素(ACTH)缺乏症,尽管定义明确,但非常罕见[1]。其临床表现与艾迪生病相似,即虚弱、疲劳、恶心、呕吐、直立性低血压、厌食、体重减轻,最常见的是低血糖[2]。然而,可能会出现罕见的存在主义[3,4]。大多数病因继发于自身免疫过程,如淋巴细胞性垂体炎[5,6]。它也可能发生在创伤性头部损伤和垂体照射后[7,8]。在新生儿和儿童时期会遇到遗传[9,10]。它可能与短暂性生长激素(GH)缺乏或甲状腺疾病有关[11,12]。此外,各种毒素与该缺陷有关[13]。在这篇通讯中,我们描述了两名患有孤立性肾上腺皮质激素(ACTH)缺乏症的患者,他们经历了两种不同的结果(短暂性和永久性),试图强调理解此类疾病及其病因病理生理学的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Isolated adrenocorticotropic hormone deficiency not always permanent
Adrenocorticotrophic Hormone (ACTH) deficiency is the most life-threatening feature of hypopituitarism. Isolated Adrenocorticotrophic Hormone (ACTH) deficiency, although well defined, is very rare [1]. Its clinical manifestations are similar to those of Addison’s disease, i.e weakness, tiredness, nausea, vomiting, orthostatic hypotension, anorexia, weight loss, and most commonly hypoglycemia [2]. However, rare presentism may occur [3,4]. Most causes are secondary to autoimmune process such as lymphocytic hypophysitis [5,6]. It may also occur after traumatic head injury and pituitary irradiation [7,8]. Genetic is encountered in the neonatal and childhood [9,10]. It might be associated with transient growth hormone (GH) deficiency or thyroid disorders [11,12]. Also, various toxins were associated with the deficiency [13]. In this communication, we describe two patients with Isolated Adrenocorticotrophic Hormone (ACTH) deficiency that experienced two different outcomes (transient vs. permanent) with an attempt to highlight the importance of understanding such disorders and its aetio-pathophysiology.
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