认知行为疗法联合米氮平对功能性消化不良患者临床疗效的影响

中华行为医学与脑科学杂志 Pub Date : 2019-12-20 DOI:10.3760/CMA.J.ISSN.1674-6554.2019.12.009

Yong Li, Xiaoyin Cong, Dan-jun He, Yinghui Li

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The treatment period was 8 weeks.All patients with FD were given mirtazapine.The combined treatment group received 8 times systemic CBT treatments at the same time.Symptom checklist-90 (SCL-90) and gastrointestinal integral scale (GIS) were evaluated in all patients before and after 8-week intervention. \n \n \nResults \nAfter 8 weeks of intervention, the total score of SCL-90 scale, somatization, compulsion, depression, paranoia and other factors in the combined treatment group were lower than those in the single group(130.26±36.18 vs 147.95±45.55, 1.34±0.44 vs 1.51±0.5, 1.66±0.50 vs 1.90±0.66, 1.47±0.52 vs 1.69±0.63, 1.48±0.49 vs 1.70±0.61, 1.47±0.50 vs 1.73±0.68, respectively)(all P<0.05). After 8 weeks of intervention, the total score of the GIS scale in the combined treatment group (6.77±5.05 vs 9.49±5.24), vomiting (0.57±0.77 vs 0.88±0.91), spastic upper abdominal pain (0.43±0.74 vs 0.90±1.08) and post-sternal discomfort (0.57±0.89 vs 1.05±1.19) were significantly lower than that of the simple drug group after intervention(6.77±5.05 vs 9.49±5.24, 0.57±0.77 vs 0.88 ±0.91, 0.43±0.74 vs 0.90±1.08 and 0.57±0.89 vs 1.05±1.19, respectively), and the differences were statistically significant (all P<0.05). \n \n \nConclusion \nCBT combined with mirtazapine in the treatment of FD is superior to drug therapy alone.CBT combined with mirtazapine can improve the emotional problems in the treatment of FD and further improving the digestive function. \n \n \nKey words: \nFunctional dyspepsia; Cognitive-behavior therapy; Randomized single-blind controlled trials; Emotional symptoms; Gastrointestinal symptoms","PeriodicalId":9940,"journal":{"name":"中华行为医学与脑科学杂志","volume":"28 1","pages":"1102-1107"},"PeriodicalIF":0.0000,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of cognitive-behavior therapy combined with mirtazapine on clinical efficacy in patients with functional dyspepsia\",\"authors\":\"Yong Li, Xiaoyin Cong, Dan-jun He, Yinghui Li\",\"doi\":\"10.3760/CMA.J.ISSN.1674-6554.2019.12.009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective \\nTo evaluate the efficacy of cognitive-behavioral therapy (CBT) combined with mirtazapine for patients with functional dyspepsia (FD). \\n \\n \\nMethods \\nTotally 121 patients with FD who met Rome Ⅳ diagnostic criteria in clinic of clinical psychiatry of a general hospital were collected.They were randomly divided into combined treatment group(n=61) and single drug group(n=60). 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引用次数: 0

摘要

目的评价认知行为疗法(CBT)联合米氮平治疗功能性消化不良(FD)的疗效。方法收集某综合医院临床精神病学门诊符合罗马Ⅳ诊断标准的FD患者121例。随机分为联合治疗组(n=61)和单药组(n=60)。治疗期8周。所有FD患者均给予米氮平治疗。联合治疗组同时接受8次全身CBT治疗。对所有患者进行干预前和干预后8周的症状量表-90 (SCL-90)和胃肠积分量表(GIS)评估。结果干预8周后，联合治疗组SCL-90量表、躯体化、强迫、抑郁、偏执等因素总分低于单独治疗组(分别为130.26±36.18 vs 147.95±45.55、1.34±0.44 vs 1.51±0.5、1.66±0.50 vs 1.90±0.66、1.47±0.52 vs 1.69±0.63、1.48±0.49 vs 1.70±0.61、1.47±0.50 vs 1.73±0.68)，差异均有统计学意义(P<0.05)。干预8周后，联合用药组GIS量表总分(6.77±5.05 vs 9.49±5.24)、呕吐总分(0.57±0.77 vs 0.88±0.91)、痉挛性上腹痛总分(0.43±0.74 vs 0.90±1.08)、胸骨后不适总分(0.57±0.89 vs 1.05±1.19)均显著低于干预后单纯用药组(分别为6.77±5.05 vs 9.49±5.24、0.57±0.77 vs 0.88±0.91、0.43±0.74 vs 0.90±1.08、0.57±0.89 vs 1.05±1.19)。差异均有统计学意义(P<0.05)。结论CBT联合米氮平治疗FD优于单纯药物治疗。CBT联合米氮平可改善FD治疗中的情绪问题，进一步改善消化功能。关键词:功能性消化不良;将认知-行为疗法;随机单盲对照试验;情感症状;胃肠道症状

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Effect of cognitive-behavior therapy combined with mirtazapine on clinical efficacy in patients with functional dyspepsia

Objective To evaluate the efficacy of cognitive-behavioral therapy (CBT) combined with mirtazapine for patients with functional dyspepsia (FD). Methods Totally 121 patients with FD who met Rome Ⅳ diagnostic criteria in clinic of clinical psychiatry of a general hospital were collected.They were randomly divided into combined treatment group(n=61) and single drug group(n=60). The treatment period was 8 weeks.All patients with FD were given mirtazapine.The combined treatment group received 8 times systemic CBT treatments at the same time.Symptom checklist-90 (SCL-90) and gastrointestinal integral scale (GIS) were evaluated in all patients before and after 8-week intervention. Results After 8 weeks of intervention, the total score of SCL-90 scale, somatization, compulsion, depression, paranoia and other factors in the combined treatment group were lower than those in the single group(130.26±36.18 vs 147.95±45.55, 1.34±0.44 vs 1.51±0.5, 1.66±0.50 vs 1.90±0.66, 1.47±0.52 vs 1.69±0.63, 1.48±0.49 vs 1.70±0.61, 1.47±0.50 vs 1.73±0.68, respectively)(all P<0.05). After 8 weeks of intervention, the total score of the GIS scale in the combined treatment group (6.77±5.05 vs 9.49±5.24), vomiting (0.57±0.77 vs 0.88±0.91), spastic upper abdominal pain (0.43±0.74 vs 0.90±1.08) and post-sternal discomfort (0.57±0.89 vs 1.05±1.19) were significantly lower than that of the simple drug group after intervention(6.77±5.05 vs 9.49±5.24, 0.57±0.77 vs 0.88 ±0.91, 0.43±0.74 vs 0.90±1.08 and 0.57±0.89 vs 1.05±1.19, respectively), and the differences were statistically significant (all P<0.05). Conclusion CBT combined with mirtazapine in the treatment of FD is superior to drug therapy alone.CBT combined with mirtazapine can improve the emotional problems in the treatment of FD and further improving the digestive function. Key words: Functional dyspepsia; Cognitive-behavior therapy; Randomized single-blind controlled trials; Emotional symptoms; Gastrointestinal symptoms

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中华行为医学与脑科学杂志

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8131

期刊介绍： "Chinese Journal of Behavioral Medicine and Brain Science" (CN 37-1468/R, ISSN 1674-6554) is a national academic journal under the supervision of the National Health Commission, sponsored by the Chinese Medical Association and Jining Medical College. The journal was founded in June 1992 and was formerly known as "Chinese Journal of Behavioral Medicine" (1992-1993) and "Chinese Behavioral Medical Science" (1994-2008). In 2009, it was renamed "Chinese Journal of Behavioral Medicine and Brain Science" with the approval of the State Administration of Press, Publication, Radio, Film and Television. The purpose of "Chinese Journal of Behavioral Medicine and Brain Science" is to implement the health and health policies of the Party and the State, implement the principle of combining theory with practice and popularization and improvement, and reflect the major progress in the theory and practical application of behavioral medicine and brain science in my country. It publishes academic papers and scientific research results in the field of behavioral medicine and brain science in my country, and has columns such as monographs/reviews, basic research, clinical research, health prevention, methods and techniques, psychological behavior and evaluation, and systematic evaluation.