毛细血管中红细胞的形状变化及其与氧气运输的可能联系

IF 1.8 4区生物学 Q3 BIOPHYSICS

Journal of Biological Physics Pub Date : 2021-11-19 DOI:10.1007/s10867-021-09594-5

Caiqun Wang, Jianfeng Li, Liutao Zhao, Ping Qian

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引用次数: 0

摘要

在这项工作中，进行了一系列的数值模拟，以获得毛细血管中红细胞在剪切力场下的稳定形状。找到了两类可能的稳定形状，即轴对称降落伞和非轴对称降落伞。如果我们假设氧气在红细胞膜上的扩散是由膜曲率介导的，则发现非轴对称降落伞由于其特殊的形状使其具有更大比例的能够向组织释放氧气的膜斑块而更有利。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Shape transformations of red blood cells in the capillary and their possible connections to oxygen transportation

In this work, a series of numerical simulations have been performed to obtain the steady shapes of red blood cells under a shear force field in the capillary. Two possible classes of steady shapes, the axisymmetric parachute and the non-axisymmetric parachute, are found. If we assume that oxygen diffusion across the red cell membrane is mediated by membrane curvature, it is found that the non-axisymmetric parachute will be more favorable due to its special shape which enables it to have a larger portion of membrane patch capable of releasing oxygen to tissues.

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来源期刊

Journal of Biological Physics 生物-生物物理

CiteScore

3.00

自引率

5.60%

发文量

审稿时长

>12 weeks

期刊介绍： Many physicists are turning their attention to domains that were not traditionally part of physics and are applying the sophisticated tools of theoretical, computational and experimental physics to investigate biological processes, systems and materials. The Journal of Biological Physics provides a medium where this growing community of scientists can publish its results and discuss its aims and methods. It welcomes papers which use the tools of physics in an innovative way to study biological problems, as well as research aimed at providing a better understanding of the physical principles underlying biological processes.