两相水-二氯甲烷体系中丙氨酸的催化苯甲酰化反应

IF 0.7 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Theoretical and Experimental Chemistry Pub Date : 2023-05-19 DOI:10.1007/s11237-023-09763-8

V. M. Anishchenko, A. M. Redko, O. M. Dykun, V. I. Rybachenko

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引用次数: 0

摘要

研究了在吡啶衍生物催化下，两相水-二氯甲烷体系中α-氨基酸(以丙氨酸为例)苯甲酰化的反相转移过程。研究了丙氨酸初始浓度、丙氨酸在溶液中的形态和催化剂初始浓度对反应速率和产物组成的影响。用4-甲基吡啶和4-甲氧基吡啶n -氧化物与双过量丙氨酸钠盐结合，可以得到产率在80%以上的2-苯并脒丙酸。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Catalytic Benzoylation of Alanine in Two-Phase Water–Dichloromethane System

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Catalytic Benzoylation of Alanine in Two-Phase Water–Dichloromethane System

The inverse phase transfer process of catalytic benzoylation of α-amino acids (on the example of alanine) in a two-phase water–dichloromethane system in the presence of pyridine derivatives as catalysts is investigated. The effect of the initial concentration of alanine, its form in solution, and the initial catalyst concentration on the reaction rate and the composition of the products is studied. It is established that using 4-methyl- and 4-methoxy pyridine N-oxides combined with a double excess of the sodium salt of alanine makes it possible to obtain 2-benzamidopropionic acid with a yield of more than 80%.

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来源期刊

Theoretical and Experimental Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

1.60

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Theoretical and Experimental Chemistry is a journal for the rapid publication of research communications and reviews on modern problems of physical chemistry such as: a) physicochemical bases, principles, and methods for creation of novel processes, compounds, and materials; b) physicochemical principles of chemical process control, influence of external physical forces on chemical reactions; c) physical nanochemistry, nanostructures and nanomaterials, functional nanomaterials, size-dependent properties of materials.