抑郁症母亲胎儿脐血丙二醛、超氧化物歧化酶和过氧化氢酶活性的评价

IF 2.4 4区医学 Q3 NEUROSCIENCES

Clinical Psychopharmacology and Neuroscience Pub Date : 2017-02-01 DOI:10.9758/cpn.2017.15.1.35

M. Camkurt, Ebru Fındıklı, M. Bakacak, F. Tolun, M. Karaaslan

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引用次数: 16

摘要

目的脐带由两条动脉和一条静脉组成，在母婴循环中起运输作用。分娩过程中胎儿脐带血(FCB)的生化分析可能有助于了解胎儿环境。在本研究中，我们旨在研究分娩过程中FCB中丙二醛(MDA)、超氧化物歧化酶(SOD)和过氧化氢酶(CAT)水平等氧化参数。方法在剖宫产术中采集FCB标本。我们的研究包括33名抑郁母亲和37名健康对照。我们研究了FCB样品中的MDA、SOD和CAT水平。结果各组间MDA (p=0.625)、SOD (p=0.940)、CAT (p=0.413)水平差异无统计学意义。结论本研究揭示了胎盘对氧化应激的保护作用。未来的研究应该包括更大的样本。

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Evaluation of Malondialdehyde, Superoxide Dismutase and Catalase Activity in Fetal Cord Blood of Depressed Mothers

Objective The umbilical cord consists of two arteries and one vein and it functions in the transport between the maternal and fetal circulation. Biochemical analysis of fetal cord blood (FCB) during delivery could be beneficial in terms of understanding the fetal environment. In this study, we aimed to investigate oxidative parameters like malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) levels in FCB during delivery. Methods We collected FCB samples during caesarean section. Our study included 33 depressed mothers and 37 healthy controls. We investigated MDA, SOD, and CAT levels in FCB samples. Results We found no significant difference between groups in terms of MDA (p=0.625), SOD (p=0.940), and CAT (p=0.413) levels. Conclusion Our study reveals probable protective effects of the placenta from oxidative stress. Future studies should include larger samples.

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来源期刊

Clinical Psychopharmacology and Neuroscience NEUROSCIENCESPHARMACOLOGY & PHARMACY-PHARMACOLOGY & PHARMACY

CiteScore

4.70

自引率

12.50%

发文量

期刊介绍： Clinical Psychopharmacology and Neuroscience (Clin Psychopharmacol Neurosci) launched in 2003, is the official journal of The Korean College of Neuropsychopharmacology (KCNP), and the associate journal for Asian College of Neuropsychopharmacology (AsCNP). This journal aims to publish evidence-based, scientifically written articles related to clinical and preclinical studies in the field of psychopharmacology and neuroscience. This journal intends to foster and encourage communications between psychiatrist, neuroscientist and all related experts in Asia as well as worldwide. It is published four times a year at the last day of February, May, August, and November.