Comparison of Mammography, Sonography, Fine-Needle Aspiration Cytology, and Excision Biopsy for the Diagnosis of Breast Lesions

Abstract Background and Objective : Problem of invasive tests in breast lesion diagnosis can be addressed by comparing non-invasive tests with final Histopathological diagnosis obtained after excision biopsy. Present study was carried out to study diagnostic utility of mammography, sonography, FNAC compared to excision biopsy for diagnosis of breast lesions Methods: Prospective Observational study was carried out among 81 women with Breast related symptoms. Digital Mammography Machine, ACUSON S3000™ Ultrasound System; FNAC and surgery for excision Biopsy were used. Sensitivity, Specificity, Accuracy, Positive and Negative Predictive values were measured and p<0.05 was considered as statistically significant. Results: Sonography and FNAC composite have sensitivity, specificity, accuracy, positive and negative predictive values 100.00%, 81.40%, 90.12%, 82.61% and 100.00% respectively. Mammography+FNAC (97.3%) is not as sensitive as Sonography+FNAC (100%), Sonography combined with FNAC is equally sensitive to excision biopsy (100%) and therefore can be used for screening purpose. Conclusion: Contrary to present guidelines which consider Mammography as most important screening tool for Breast Cancer, combination of Sonography and FNAC can be considered equally reliable.