唐氏综合征儿童瘦素、脂联素水平与营养状况的关系

Q4 Social Sciences
A. Utari, D. G. Panunggal, Tithasiri Audi Rahardjo, Wiwik Lestari, F. Cayami, T. Winarni
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引用次数: 0

摘要

背景:患有唐氏综合症(DS)的儿童与肥胖有关。瘦素和脂联素也是DS患者肥胖及其合并症的重要预测因子。然而,关于DS患儿瘦素和脂联素的数据有限,尤其是营养不良的患儿。本研究旨在探讨瘦素水平、脂联素水平和营养状况在儿童退行性痴呆中的作用。方法:对40例1 ~ 5岁的退行性椎体滑移患儿进行横断面研究。测量身高和体重,然后用DS生长图解释生长情况。测定身高体重Z-Score (WHZ)和年龄身高Z-Score (HAZ),测量中上臂围(MUAC)。采用酶联免疫吸附法(ELISA)检测血清瘦素和脂联素。曼-惠特尼试验比较了正常组和消瘦组的瘦素和脂联素水平,而斯皮尔曼的分析则将实验室结果和人体测量参数联系起来。结果:40例患儿(男23例,女17例),中位年龄25.5个月。40名DS儿童中有10名(25%)被浪费,瘦素的浪费明显低于正常儿童。此外,瘦素与WHZ显著相关(r = 0.415;p = 0.008), MUAC (r = 0.427;P = 0.006),而脂联素与这些人体测量变量在消瘦组和非消瘦组均无显著相关。结论:瘦素与WHZ和MUAC有关,且消瘦儿童DS的WHZ和MUAC降低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between Leptin, Adiponectin Levels, and Nutritional Status in Children with Down Syndrome
Background: Children with Down Syndrome (DS) have been associated with obesity. Leptin and adiponectin were also significant predictors of obesity and its comorbidity in DS. However, there was limited data regarding leptin and adiponectin in children with DS, particularly who were undernutrition. This study aimed to seek the role of leptin levels, adiponectin levels, and nutritional status in children with DS. Methods: This cross-sectional study was conducted on 40 children with DS aged 1 - 5 years. Height and weight were measured, and then the growth was interpreted using a DS growth chart. The Weight for Height Z-Score (WHZ) and Height for Age Z-Score (HAZ) were determined, and Mid-Upper Arm Circumference (MUAC) was measured. Leptin and adiponectin serum were analyzed using the enzyme-linked immunosorbent assay (ELISA) method. Mann-Whitney test was done to compare leptin and adiponectin levels in normal and wasted groups, while Spearman’s analysis was carried out to correlate laboratory results and anthropometric parameters. Results: Forty children participated (23 males, 17 females) with a median age was 25.5 months. Ten out of 40 children with DS (25%) were wasted and leptin was significantly lower in wasted compared to normal children. In addition, leptin was significantly correlated with WHZ (r = 0.415; p = 0.008), and MUAC (r = 0.427; p = 0.006), while adiponectin did not significantly correlate with those anthropometric variables in both wasted or non-wasted groups. Conclusion: Leptin is associated with WHZ and MUAC, and it decreases in wasted children with DS.
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来源期刊
Journal of Intellectual Disability - Diagnosis and Treatment
Journal of Intellectual Disability - Diagnosis and Treatment Social Sciences-Health (social science)
CiteScore
1.00
自引率
0.00%
发文量
29
期刊介绍: The journal aims to describe the research work on Intellectual Disability Diagnosis and Treatment in children and adults. It covers not just the technical aspects of the procedures in prenatal, newborn and postnatal screening, but also the impact which the process of testing and treatment has on individuals, parents, families and public-health in general. The journal seeks to publish, but is a not restricted to, Genetic Intellectual Disability Syndromes, using a range of approaches from medicine, psychiatry, psychology, pharmacy, biology, epidemiology, bioinformatics, biopharmaceutical to association and population studies as well as sociological, ethical, philosophical, legal and quality control issues with the ultimate goal of advancing the knowledge on the diagnosis, prevention, and treatment of the Intellectual Disabilities. The journal publishes original research articles, review articles, case reports and short communications(Letter article).
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