电化学传感器测定某些抗真菌唑类药物的研究进展

Bianca-Maria Ţuchiu, Raluca-Ioana Ștefan-van Staden, J. V. van Staden
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引用次数: 2

摘要

抗真菌剂是用于治疗由各种类型的真菌引起的真菌感染的基本药物。由于其作用机制,这些药物会产生严重的不良反应,与多种其他药物相互作用,并对环境产生负面影响。因此,需要准确、灵敏和可靠的检测方法,以最大限度地减少并可能避免其潜在的负面影响。尽管到目前为止,经典方法已被证明在检测这些药物方面是有效的,但它们的一些缺点导致科学界将重点放在电化学方法上,因为它们更简单、更灵敏,并且需要更少的样本量和最少的样本预处理。这篇小型综述的重点是2017年至2022年间开发的用于检测和量化抗真菌唑类药物的电化学传感器,强调了它们的反应特性、灵敏度和在真实样品分析中的适用性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Review—Electrochemical Sensors Used for the Determination of Some Antifungal Azoles
Antifungal agents are essential drugs used to treat fungal infections caused by various types of fungi. Due to their mechanism of action, these drugs bear serious adverse reactions, interact with a wide range of other drugs, and negatively impact the environment. Therefore, there is a need for accurate, sensitive, and reliable detection methods to minimize and possibly avoid their potentially negative effects. Even though so far classical methods have proven to be effective in detecting these drugs, some of their disadvantages have led the scientific community to focus its efforts on electrochemical methods, as they are simpler to use, more sensitive, and require a smaller quantity of sample and minimal sample pretreatment. This mini-review focuses on electrochemical sensors developed between 2017 and 2022 to detect and quantify antifungal azoles, highlighting their response characteristics, sensitivity, and applicability in real samples analysis.
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