三叶鼠尾草提取物对大鼠十二指肠平滑肌的解痉作用

Q2 Social Sciences

Studies on Ethno-Medicine Pub Date : 2019-04-08 DOI:10.31901/24566772.2019/13.03.588

Islam H. AlTarawneh

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引用次数: 1

摘要

三叶鼠尾草被认为是约旦和中东经常用于治疗包括胃肠道疾病在内的多种疾病的替代药物的药用植物之一。研究了丹参叶水提物对大鼠离体十二指肠平滑肌的影响。采用隔离器官浴。用乙酰胆碱、氯化钾（KCl）和氯化钡（BaCl2）等试剂对样本进行预收缩。然后加入浓度为0.1–3mg/ml的三叶草提取物，收集收缩抑制信号，追踪并分析其效果。丹参叶提取物对大鼠十二指肠自发收缩具有剂量依赖性的抑制作用，尤其是对乙酰胆碱的抑制作用。KCl或BaCl2均未发现明显的抑制作用。水性三叶草叶提取物显示出抗痉挛作用，其作用是通过抑制乙酰胆碱来实现的，这解释了其传统上用于缓解胃肠道疾病。

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Spasmolytic Effects of Salvia triloba Leaf Extract on Smooth Muscles of the Duodenum in Rats

Salvia triloba is considered one of the medicinal plant that is frequently used in Jordan and the Middle East in alternative medicine against a number of diseases, including gastrointestinal disorders. The effects of Salvia triloba leaf aqueous extracton the isolated smooth muscles of the rat duodenum were investigated. Isolated organ bath was adopted. The specimens were pre-contracted with reagents such as acetylcholine, potassium chloride (KCl), and barium chloride (BaCl2). .Then Salvia triloba extract was added in concentrations of 0.1–3mg/ml. The contraction-inhibition signals were collected and the effect was traced and analyzed. The aqueous Salvia triloba leaf extract inhibited the spontaneous contraction of rat duodenum in a dose-dependent manner, especially in the inhibition of acetylcholine. No significant inhibition was noticed with either KCl or BaCl2. The aqueous Salvia triloba leaf extract showed antispasmodic action which took its effect through the inhibition of acetylcholine that explained its use traditionally in alleviating gastrointestinal disorders.

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来源期刊

Studies on Ethno-Medicine Social Sciences-Cultural Studies

CiteScore

0.50

自引率

0.00%

发文量

期刊介绍： Studies on Ethno-Medicine is a peer reviewed, internationally circulated journal. It publishes reports of original research, theoretical articles, timely reviews, brief communications, book reviews and other publications in the interdisciplinary field of ethno-medicine. The journal serves as a forum for physical, social and life scientists as well as for health professionals. The transdisciplinary areas covered by this journal include, but are not limited to, Physical Sciences, Anthropology, Sociology, Geography, Life Sciences, Environmental Sciences, Botany, Agriculture, Home Science, Zoology, Genetics, Biology, Medical Sciences, Public Health, Demography and Epidemiology. The journal publishes basic, applied and methodologically oriented research from all such areas. The journal is committed to prompt review, and priority publication is given to manuscripts with novel or timely findings, and to manuscript of unusual interest. Further, the manuscripts are categorised under three types, namely - Regular articles, Short Communications and Reviews. The researchers are invited to submit original papers in English (papers published elsewhere or under consideration elsewhere shall not be considered).