使用低场单侧磁共振系统定量肝脏脂肪

IF 1.1 4区 物理与天体物理 Q4 PHYSICS, ATOMIC, MOLECULAR & CHEMICAL
Cornelius von Morze, Tyler Blazey, Mark S. Conradi
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引用次数: 0

摘要

非酒精性脂肪性肝病(NAFLD)是一种非常普遍的疾病,对公众健康有很大影响,但在个体患者中仍未被发现。MRI质子密度分数(MRI- pdff)是测量肝脏脂肪含量的金标准方法,但对于这种弥漫性肝病过程可能被认为是“过度杀伤”。目前迫切需要一种更简单的非侵入性方法来测量和跟踪肝脏脂肪含量,新兴的单侧永磁磁共振技术非常适合。在本研究中,我们评估了Utsuzawa和Fukushima于2017年首次描述的桶状磁铁系统在量化肝脏脂肪含量方面的潜力。我们在油水乳液中测试了这种新的单侧磁共振系统,随后在正常和肥鸭肝脏的离体组织样本中测试了这种系统。在油水乳液中,该系统在MR信号的贝叶斯分析得出的脂肪信号幅度与已知含油量之间提供了良好的线性一致性。在正常和脂肪肝样本之间,也观察到水和脂肪信号幅度的明显差异。区分脂肪含量差异的能力仅为5%,这表明使用为人类研究设计的放大系统对NAFLD的医学管理具有明确的潜在临床意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Quantifying Liver Fat Using a Low-Field Unilateral MR System

Quantifying Liver Fat Using a Low-Field Unilateral MR System

Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent condition with a large impact on public health, but remains largely undetected among individual patients. MRI proton density fraction (MRI-PDFF) is the gold standard method for measuring liver fat content, but might be regarded as “overkill” for this diffuse liver disease process. There is a pressing current medical need for simpler non-invasive approaches to measure and track liver fat content over time, for which emerging unilateral permanent magnet MR technology is uniquely suited. In this study, we evaluate the potential of the barrel magnet system first described by Utsuzawa and Fukushima in 2017 to quantify liver fat content. We tested this novel unilateral MR system in oil–water emulsions and subsequently with ex vivo tissue samples from normal and fatty duck livers. In oil–water emulsions, the system provided good linear agreement between fat signal amplitudes derived from Bayesian analysis of MR signals and known oil content. Clear differences in water and fat signal amplitudes were also observed between normal and fatty liver samples. The ability to discriminate differences in fat content as little as 5% demonstrates clear potential clinical relevance for medical management of NAFLD using a scaled-up system designed for human studies.

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来源期刊
Applied Magnetic Resonance
Applied Magnetic Resonance 物理-光谱学
CiteScore
1.90
自引率
10.00%
发文量
59
审稿时长
2.3 months
期刊介绍: Applied Magnetic Resonance provides an international forum for the application of magnetic resonance in physics, chemistry, biology, medicine, geochemistry, ecology, engineering, and related fields. The contents include articles with a strong emphasis on new applications, and on new experimental methods. Additional features include book reviews and Letters to the Editor.
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