替诺福韦引起的急性肾损伤和严重贫血:四例患者的病例系列

Advancements in journal of urology and nephrology Pub Date : 2019-12-20 DOI:10.33140/ajun.01.01.08

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摘要

我们报告了四例与使用替诺福韦（TDF）相关的非典型急性肾损伤（AKI）病例。观察到胰蛋白酶升高、血糖正常的糖尿病、异常高蛋白尿、高血清磷酸盐和严重贫血。TDF停药后，所有患者的肾小球滤过率（GFR）和血红蛋白水平均升高，但只有一名患者病情完全缓解。临床医生应该意识到这种非典型TDF诱导的AKI表现具有终末期肾脏疾病的特征。

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Tenofovir Induced Acute Kidney Injury and Severe Anemia: A Case Series of Four Patients

We report four cases of atypical acute kidney injury (AKI) associated with the used of Tenofovir (TDF). Elevated creatinine, normoglycemic glycosuria with unusual high proteinuria, high serum phosphate and severe anemia were observed. After withdrawal of TDF, glomerular filtration rate (GFR) and hemoglobin level increase in all the patients, but only one patient have a complete remission. Clinician should be aware of this atypical TDF induced AKI presentation with end stage Kidney Disease characteristics.

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Advancements in journal of urology and nephrology

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