无前脑畸形死胎的脑内视网膜样色素组织。

IF 0.8 4区医学 Q4 CLINICAL NEUROLOGY

Clinical Neuropathology Pub Date : 2022-04-01 DOI:10.5414/NP301453

Hao Li, Qi Zhang, L. Ang

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引用次数: 0

摘要

在24周孕龄时引产半叶前脑畸形死产胎儿。虽然他的眼睛外表看起来没什么特别之处，但却没有视神经。下丘脑间脑区腹侧可见双侧含有黑色素的上皮样细胞区。免疫组织化学鉴定显示细胞为神经上皮细胞，具有视网膜色素上皮的特征。这些发现反映了无前脑畸形的眼睛发育异常，特别是当加上视觉系统的其他结构缺陷时。

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Intracerebral retina-like pigmented tissue in a stillborn fetus with holoprosencephaly.

A stillbirth fetus with semilobar holoprosencephaly was induced at 24 weeks gestational age. While the eyes appeared unremarkable externally, there was an absence of optic nerves. At the ventral hypothalamicdiencephalic region there was an area of bilateral epithelioid cells containing melanin. Immunohistochemical characterization revealed the cells to be of neuroepithelial origin with features of retinal pigment epithelium. These findings reflect abnormalities in eye development in holoprosencephaly, especially when coupled with other structural defects in the visual system.

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来源期刊

Clinical Neuropathology 医学-病理学

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Clinical Neuropathology appears bi-monthly and publishes reviews and editorials, original papers, short communications and reports on recent advances in the entire field of clinical neuropathology. Papers on experimental neuropathologic subjects are accepted if they bear a close relationship to human diseases. Correspondence (letters to the editors) and current information including book announcements will also be published.