{"title":"新型DABCO酸性离子液体作为合成噻唑烷-4-酮衍生物的绿色方案及对人乳腺癌细胞系的细胞毒活性评价","authors":"Priyanka Pinate , Sangita Makone","doi":"10.1080/17415993.2022.2099223","DOIUrl":null,"url":null,"abstract":"<div><p>A novel [C<sub>4</sub>H<sub>10</sub>-DABCO][ClO<sub>4</sub>]<sub>2</sub> DABCO based protic acid supported ionic liquid has been synthesized, characterized, and evaluated as an efficient, economic, and reusable catalyst for the one pot, three component synthesis of 1,3-thiazolidin-4-one in an aqueous medium with high to excellent yield. This study compares DABCO based ionic liquids [H<sub>2</sub>-DABCO][HSO<sub>4</sub>]<sub>2</sub>, [H<sub>2</sub>-DABCO][H<sub>2</sub>PO<sub>4</sub>]<sub>2</sub>, [H<sub>2</sub>-DABCO][ClO<sub>4</sub>]<sub>2</sub>, and [C<sub>4</sub>H<sub>10</sub>-DABCO][ClO<sub>4</sub>]<sub>2</sub> to highlight the impact of cations and anions on the catalytic applicability and moisture-resistance properties. The DABCO based Bifunctional Acidic Ionic Liquid (DBAIL) catalyst was effectively recycled five times without losing significant catalytic activity. Five of the synthesized derivatives were evaluated for their cytotoxic activity against the MCF-7 cell line using MTT assay, and the compounds showed moderate to good activity.</p></div>","PeriodicalId":17081,"journal":{"name":"Journal of Sulfur Chemistry","volume":"44 1","pages":"Pages 20-36"},"PeriodicalIF":2.1000,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Novel DABCO based acidic ionic liquid as a green protocol for the synthesis of thiazolidin-4-one derivatives and cytotoxic activity evaluation on human breast cancer cell line\",\"authors\":\"Priyanka Pinate , Sangita Makone\",\"doi\":\"10.1080/17415993.2022.2099223\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A novel [C<sub>4</sub>H<sub>10</sub>-DABCO][ClO<sub>4</sub>]<sub>2</sub> DABCO based protic acid supported ionic liquid has been synthesized, characterized, and evaluated as an efficient, economic, and reusable catalyst for the one pot, three component synthesis of 1,3-thiazolidin-4-one in an aqueous medium with high to excellent yield. This study compares DABCO based ionic liquids [H<sub>2</sub>-DABCO][HSO<sub>4</sub>]<sub>2</sub>, [H<sub>2</sub>-DABCO][H<sub>2</sub>PO<sub>4</sub>]<sub>2</sub>, [H<sub>2</sub>-DABCO][ClO<sub>4</sub>]<sub>2</sub>, and [C<sub>4</sub>H<sub>10</sub>-DABCO][ClO<sub>4</sub>]<sub>2</sub> to highlight the impact of cations and anions on the catalytic applicability and moisture-resistance properties. The DABCO based Bifunctional Acidic Ionic Liquid (DBAIL) catalyst was effectively recycled five times without losing significant catalytic activity. Five of the synthesized derivatives were evaluated for their cytotoxic activity against the MCF-7 cell line using MTT assay, and the compounds showed moderate to good activity.</p></div>\",\"PeriodicalId\":17081,\"journal\":{\"name\":\"Journal of Sulfur Chemistry\",\"volume\":\"44 1\",\"pages\":\"Pages 20-36\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2023-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Sulfur Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1741599323000454\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Sulfur Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1741599323000454","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Novel DABCO based acidic ionic liquid as a green protocol for the synthesis of thiazolidin-4-one derivatives and cytotoxic activity evaluation on human breast cancer cell line
A novel [C4H10-DABCO][ClO4]2 DABCO based protic acid supported ionic liquid has been synthesized, characterized, and evaluated as an efficient, economic, and reusable catalyst for the one pot, three component synthesis of 1,3-thiazolidin-4-one in an aqueous medium with high to excellent yield. This study compares DABCO based ionic liquids [H2-DABCO][HSO4]2, [H2-DABCO][H2PO4]2, [H2-DABCO][ClO4]2, and [C4H10-DABCO][ClO4]2 to highlight the impact of cations and anions on the catalytic applicability and moisture-resistance properties. The DABCO based Bifunctional Acidic Ionic Liquid (DBAIL) catalyst was effectively recycled five times without losing significant catalytic activity. Five of the synthesized derivatives were evaluated for their cytotoxic activity against the MCF-7 cell line using MTT assay, and the compounds showed moderate to good activity.
期刊介绍：
The Journal of Sulfur Chemistry is an international journal for the dissemination of scientific results in the rapidly expanding realm of sulfur chemistry. The journal publishes high quality reviews, full papers and communications in the following areas: organic and inorganic chemistry, industrial chemistry, materials and polymer chemistry, biological chemistry and interdisciplinary studies directly related to sulfur science.
Papers outlining theoretical, physical, mechanistic or synthetic studies pertaining to sulfur chemistry are welcome. Hence the target audience is made up of academic and industrial chemists with peripheral or focused interests in sulfur chemistry. Manuscripts that truly define the aims of the journal include, but are not limited to, those that offer: a) innovative use of sulfur reagents; b) new synthetic approaches to sulfur-containing biomolecules, materials or organic and organometallic compounds; c) theoretical and physical studies that facilitate the understanding of sulfur structure, bonding or reactivity; d) catalytic, selective, synthetically useful or noteworthy transformations of sulfur containing molecules; e) industrial applications of sulfur chemistry; f) unique sulfur atom or molecule involvement in interfacial phenomena; g) descriptions of solid phase or combinatorial methods involving sulfur containing substrates. Submissions pertaining to related atoms such as selenium and tellurium are also welcome. Articles offering routine heterocycle formation through established reactions of sulfur containing substrates are outside the scope of the journal.
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