取代2-(2-(呋喃-2-羰基)腙)-4-氧丁酸的合成、分子内环化及抗炎活性

Q4 Materials Science

Chimica Techno Acta Pub Date : 2022-12-16 DOI:10.15826/chimtech.2023.10.1.02

S. N. Igidov, D. V. Lipin, A. Turyshev, S. V. Chashchina, D. A. Shipilovskikh, O. V. Zvereva, K. A. Mitusova, P. Silaichev, N. Igidov

{"title":"取代2-(2-(呋喃-2-羰基)腙)-4-氧丁酸的合成、分子内环化及抗炎活性","authors":"S. N. Igidov, D. V. Lipin, A. Turyshev, S. V. Chashchina, D. A. Shipilovskikh, O. V. Zvereva, K. A. Mitusova, P. Silaichev, N. Igidov","doi":"10.15826/chimtech.2023.10.1.02","DOIUrl":null,"url":null,"abstract":"A method was proposed for the synthesis of substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids by the reaction of substituted 2,4-dioxobut-2-enoic acids with furan-2-carbohydrazide. It was found that substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids undergo intramolecular cyclization in the presence of propionic anhydride to form the corresponding N'-(2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides. The anti-inflammatory activity of the obtained compounds was studied. It was found that the obtained compounds have pronounced anti-inflammatory activity.","PeriodicalId":9964,"journal":{"name":"Chimica Techno Acta","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic Acids\",\"authors\":\"S. N. Igidov, D. V. Lipin, A. Turyshev, S. V. Chashchina, D. A. Shipilovskikh, O. V. Zvereva, K. A. Mitusova, P. Silaichev, N. Igidov\",\"doi\":\"10.15826/chimtech.2023.10.1.02\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A method was proposed for the synthesis of substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids by the reaction of substituted 2,4-dioxobut-2-enoic acids with furan-2-carbohydrazide. It was found that substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids undergo intramolecular cyclization in the presence of propionic anhydride to form the corresponding N'-(2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides. The anti-inflammatory activity of the obtained compounds was studied. It was found that the obtained compounds have pronounced anti-inflammatory activity.\",\"PeriodicalId\":9964,\"journal\":{\"name\":\"Chimica Techno Acta\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-12-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chimica Techno Acta\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15826/chimtech.2023.10.1.02\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Materials Science\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chimica Techno Acta","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15826/chimtech.2023.10.1.02","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Materials Science","Score":null,"Total":0}

引用次数: 2

摘要

提出了以取代的2,4-二氧丁-2-烯酸与呋喃-2-碳酰肼反应合成取代的2-(2-(呋喃-2-羰基)腙)-4-氧丁酸的方法。发现取代的2-(2-(呋喃-2-羰基)腙)-4-氧丁酸在丙酸酐存在下发生分子内环化，形成相应的N'-(2-氧呋喃-3(2H)-乙基)呋喃-2-碳腙。研究了所得化合物的抗炎活性。实验发现所得化合物具有明显的抗炎活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic Acids

A method was proposed for the synthesis of substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids by the reaction of substituted 2,4-dioxobut-2-enoic acids with furan-2-carbohydrazide. It was found that substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids undergo intramolecular cyclization in the presence of propionic anhydride to form the corresponding N'-(2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides. The anti-inflammatory activity of the obtained compounds was studied. It was found that the obtained compounds have pronounced anti-inflammatory activity.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Chimica Techno Acta Chemical Engineering-Chemical Engineering (all)

CiteScore

1.00

自引率

0.00%

发文量

审稿时长

4 weeks