取代2-(2-(呋喃-2-羰基)腙)-4-氧丁酸的合成、分子内环化及抗炎活性

Q4 Materials Science

Chimica Techno Acta Pub Date : 2022-12-16 DOI:10.15826/chimtech.2023.10.1.02

S. N. Igidov, D. V. Lipin, A. Turyshev, S. V. Chashchina, D. A. Shipilovskikh, O. V. Zvereva, K. A. Mitusova, P. Silaichev, N. Igidov

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引用次数: 2

摘要

提出了以取代的2,4-二氧丁-2-烯酸与呋喃-2-碳酰肼反应合成取代的2-(2-(呋喃-2-羰基)腙)-4-氧丁酸的方法。发现取代的2-(2-(呋喃-2-羰基)腙)-4-氧丁酸在丙酸酐存在下发生分子内环化，形成相应的N'-(2-氧呋喃-3(2H)-乙基)呋喃-2-碳腙。研究了所得化合物的抗炎活性。实验发现所得化合物具有明显的抗炎活性。

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Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic Acids

A method was proposed for the synthesis of substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids by the reaction of substituted 2,4-dioxobut-2-enoic acids with furan-2-carbohydrazide. It was found that substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids undergo intramolecular cyclization in the presence of propionic anhydride to form the corresponding N'-(2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides. The anti-inflammatory activity of the obtained compounds was studied. It was found that the obtained compounds have pronounced anti-inflammatory activity.

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来源期刊

Chimica Techno Acta Chemical Engineering-Chemical Engineering (all)

CiteScore

1.00

自引率

0.00%

发文量

审稿时长

4 weeks