不同血小板指数与严重疟疾不同临床亚组的相关性研究

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-03-01 DOI:10.4314/mmj.v35i1.2

Abdullah Algın, Serdar Özdemir, Ebubekir Arslan, Abuzer Özkan

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引用次数: 0

摘要

目的评价血小板计数、平均血小板体积、血小板分布宽度和血小板质量指数对疟疾严重程度的预测能力。材料和方法本研究是在索马里一家三级医院进行的回顾性队列研究。患者分为严重和非严重疟疾。我们比较各组血小板计数、平均血小板体积、血小板分布宽度和血小板质量指数。结果131例患者纳入最终分析。其中非重度疟疾77例(58.7%)，重度疟疾54例(41.3%)。多因素分析显示，两组患者血小板计数、平均血小板体积、血小板分布宽度、血小板质量指数差异无统计学意义(p值分别为0.183、0.323、0.204、0.139)。在受试者工作特征分析中，血小板计数、平均血小板体积、血小板分布宽度和血小板质量指数曲线下面积分别为0.699、0.619、0.504和0.675。结论血小板指数中，血小板计数、平均血小板体积、血小板分布宽度和血小板质量指数均不能作为预测疟疾严重程度的临床指标。

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Investigating the association between various platelet indices and different clinical sub-groups of severe malaria.

Aim: To evaluate the ability of platelet count, mean platelet volume, platelet distribution width, and platelet mass index to predict the severity of malaria.

Materials and methods: This study was conducted as a retrospective cohort study at a tertiary hospital in Somali. Patients grouped as severe and non-severe malaria. We compared groups in terms of platelet count, mean platelet volume, platelet distribution width, and platelet mass index.

Results: A total of 131 patients were included in the final analysis. Of the patients, 77 (58.7%) had non-severe malaria, and 54 (41.3%) had severe malaria. The multivariate analysis revealed that there was no significant difference between the groups in terms of platelet count, mean platelet volume, platelet distribution width, and platelet mass index (p: 0.183, 0.323, 0.204, and 0.139, respectively). In the receiver operating characteristic analysis, the area under the curve values for platelet count, mean platelet volume, platelet distribution width, and platelet mass index were 0.699, 0.619, 0.504, and 0.675, respectively.

Conclusion: Of the platelet indices, platelet count, mean platelet volume, platelet distribution width, and platelet mass index were not clinically significant markers that could be used to predict the severity of malaria.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.