沙特阿拉伯不同年龄段肥胖与多发性硬化症的关系:一项多中心病例对照研究

IF 1.2 4区医学 Q4 CLINICAL NEUROLOGY

Neurosciences Pub Date : 2022-04-01 DOI:10.17712/nsj.2022.2.20210121

Osama Al-Wutayd, A. Mohamed, J. Saeedi, Hessa S. Alotaibi, M. A. Al Jumah

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引用次数: 0

摘要

目的:确定沙特阿拉伯不同年龄阶段的体型是否与MS风险增加有关。方法:本研究纳入2016-2017年沙特阿拉伯利雅得、吉达和达曼三个城市诊所和医院病房的307例MS患者和307例健康对照。我们使用Stunkard的标准身体轮廓来确定参与者在不同年龄阶段(学校水平)的身体尺寸(从1到9)。我们计算了校正优势比(AORs)和95%置信区间(CIs)，并进行了年龄和性别校正后的多变量分析。结果:中等学校时期体型大(轮廓6-9)和体型5与MS风险增加相关(AOR: 3.75, 95% CI: 1.10-12.78; AOR: 3.75, 95% CI: 1.41-10)。与体型3相比，中学时期体型最小(1)的儿童患多发性硬化症的风险较低(AOR: 0.39, 95% CI: 0.17-0.90)。结论:中学阶段(13-15岁)超重和肥胖与MS风险增加有关，尤其是女性。

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Association between obesity during different age periods and multiple sclerosis in Saudi Arabia: A multicenter case–control study

Objectives: To determine whether body size in different age periods is associated with an increased risk of MS in Saudi Arabia. Methods: This study included 307 MS patients and 307 healthy controls from clinics and hospital wards in three cities (Riyadh, Jeddah, and Dammam) in Saudi Arabia (2016-2017). We used Stunkard’s standard body silhouettes to determine the participants’ body sizes (from 1 to 9) during different age periods (school levels). We calculated adjusted odds ratios (AORs) and 95% confidence intervals (CIs) and performed multivariable analysis adjusted for age and gender. Results: Large body sizes (silhouettes 6–9) and body size 5 during intermediate school were associated with an increased risk of MS (AOR: 3.75, 95% CI: 1.10–12.78 and AOR: 3.75, 95% CI: 1.41–10, respectively). The smallest body size (1) during intermediate school was associated with a lower risk of MS (AOR: 0.39, 95% CI: 0.17–0.90) compared to body size 3. Conclusion: Overweight and obesity during the intermediate school period (ages 13–15 years) are associated with an increased risk of MS, particularly among females.

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来源期刊

Neurosciences 医学-临床神经学

CiteScore

1.40

自引率

0.00%

发文量

审稿时长

4.5 months

期刊介绍： Neurosciences is an open access, peer-reviewed, quarterly publication. Authors are invited to submit for publication articles reporting original work related to the nervous system, e.g., neurology, neurophysiology, neuroradiology, neurosurgery, neurorehabilitation, neurooncology, neuropsychiatry, and neurogenetics, etc. Basic research withclear clinical implications will also be considered. Review articles of current interest and high standard are welcomed for consideration. Prospective workshould not be backdated. There are also sections for Case Reports, Brief Communication, Correspondence, and medical news items. To promote continuous education, training, and learning, we include Clinical Images and MCQ’s. Highlights of international and regional meetings of interest, and specialized supplements will also be considered. All submissions must conform to the Uniform Requirements.