用红外光谱测定法鉴定某些药物中含有扑热息痛的复合成分

IF 0.5 Q4 PHARMACOLOGY & PHARMACY
Анна Степановна Саушкина, Любовь Николаевна Зинчук, Михаил Андреевич Денисов, Владислав Александрович Шокуров, Д. В. Гончаров
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引用次数: 0

摘要

假药是对人民健康的严重威胁。在许多情况下,它们在进货质量控制过程中被识别为符合监管文件对指标“说明”、“包装”、“标记”的要求。然而,为了识别复杂的假药,仅仅对药物进行视觉评估是不够的。目的利用红外光谱法沿总光谱对潜在假冒或劣质药物进行筛选评估。材料和方法。研究对象可在国内外制造商生产的免费商用片剂“对乙酰氨基酚Extratab”、“Solpadein-fast”、“Citrapac”、“柠檬蒙P”、“Ascofen-P”中获得,符合现行监管文件的要求。研究是在红外傅立叶分光光度计“FSM1201”上进行的。结果和讨论。在“柠檬蒙P”、“Ascophen-P”、“Citrapac”、“对乙酰氨基酚Extratab”、“Solpadein Fast”片剂的例子中,显示了使用总红外光谱作为真实性主要筛选指标的可能性。研究表明,组成相似的药物的总红外光谱反映了一个制造商产品序列样品的相似性和不同制造商产品序列样本的差异性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ИДЕНТИФИКАЦИЯ НЕКОТОРЫХ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ СЛОЖНОГО СОСТАВА, СОДЕРЖАЩИХ ПАРАЦЕТАМОЛ, МЕТОДОМ ИК-СПЕКТРОМЕТРИИ
A serious threat to the health of the population is falsified medicines. In a number of cases, they are identified in the process of incoming quality control for compliance with the requirements of regulatory documents for indicators “Description”, “Packaging”, “Marking”. However, in order to identify sophisticated counterfeits, only a visual assessment of the drug is not enough. Purpose screening evaluation of potentially counterfeited or poor-quality drugs using the IR spectrometry along the total spectrum. Materials and methods. The objects of research were available in freely available commercially available tablets produced by domestic and foreign manufacturers “Paracetamol Extratab”, “Solpadein fast”, “Citrapac”, “Citramon P”, “Ascofen-P”,  corresponding to the requirements of the current regulatory documents. The studies were carried out on a Fourier-Spectrophotometer infrared “FSM 1201”. Results and discussion. On the example of the tablets “Citramon P”, “Ascophen-P”, “Citrapac”, “Paracetamol Extratab”, “Solpadein Fast” the possibility of using the total IR spectra as a primary screening index of authenticity is shown. It was established that the total IR spectra of medicines of similar composition reflect the similarity of serial samples of the products of one manufacturer and the difference in serial samples of products of different manufacturers.
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来源期刊
CiteScore
1.10
自引率
16.70%
发文量
34
审稿时长
8 weeks
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